Renal Colic
Conditions
Keywords
Renal pain, lornoxicam, pethidine, emergency room, ketamine
Brief summary
Patients with acute renal colic divided into 2 groups. Group L administered ornoxicam and Group P administered pethidine and VAS was recorded for both groups.
Detailed description
Prospective, randomized, double blind clinical study including 120 patients with acute renal pain admitted in emergency department. They were randomly assigned to one of two groups using a computer-generated table. Group L received lornoxicam 8 mg IV plus 0.15 mg.kg-1 ketamine and Group P received pethidine 50 mg IV. Parameters were observed at baseline and after 0, 15, 30, 45 and 1 hour of drug treatment. The efficacy of the drug was measured by observing: patient rated pain, time to pain relief, rate of pain recurrence, the need for rescue analgesia, adverse events and functional status.
Interventions
DRUGLornoxicam and mepridine
compare the effect of each to control pain
Sponsors
Ain Shams University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Caregiver)
Eligibility
Sex/Gender
ALL
Age
20 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* Patients, who did not administer any analgesics at least within the last two hours. - - * Patients aged between 20-60 years.
Exclusion criteria
* Patients with previous renal surgery * liver and renal failure * hypersensitivity to lornoxicam, ketamine and pethidine, history of peptic ulcer, * gastrointestinal bleeding and perforation, * hypertensive and history of cardiac diseases * pregnancy and lactation and * urine examination showing more than 5 leukocytes suggestive of pyuria. * patients with hyperthyroidism are excluded
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in pain feeling | 0hours, 1hour,2hours,3hours,4hours after drug administration in both groups | We assess this through Visual analogue scale score to assess pain due to renal colic, number 10 means maximum pain feeling and 0 means no pain at all. |
| No need for more analgesics | Registration of analgesic needed for 12h after the attack | Rescue analgesics administration |
Countries
Egypt
Outcome results
None listed