Amblyopia
Conditions
Keywords
Amblyopia
Brief summary
The purpose for this study is to investigate spectacle compliance and treatment outcome in bilateral and unilateral refractive amblyopia in children age 3 to \<10 years old. Specifically, how frequently and for what duration is spectacle wear necessary to maximize best-corrected visual acuity by spectacle correction alone.
Detailed description
The purpose for this study is to investigate spectacle compliance and treatment outcome in bilateral and unilateral refractive amblyopia in children age 3 to \<10 years old. Specifically, how frequently and for what duration is spectacle wear necessary to maximize best-corrected visual acuity by spectacle correction alone.
Interventions
OTHERPrescription glasses for unilateral amblyopia
Correction of asymmetric refractive errors with lenses
OTHERPrescription glasses for bilateral amblyopia
Correction of refractive error with prescription glasses both eyes
Sponsors
Salus University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
3 Years to 10 Years
Inclusion criteria
* Age 3 to \< 10 years * Subjects and their parent/guardian speak and understand English adequately to complete the study protocol and give informed consent. Subjects have the ability to adhere to the study visit schedule. * All refractive error measures below will be determined by cycloplegic retinoscopy by one of the study investigators during the comprehensive eye exam. Measures are in minus cylinder spectacle prescription format. Inclusion criteria for bilateral amblyopia: The major eligibility criteria include: * Best-corrected visual acuity of \<20/30 each eye. * For hypermetropia: * Spherical equivalent \>+2.00 D each eye. * Spherical equivalent difference between eyes \<1.25 D. * For astigmatism without hypermetropia criteria above or myopia criteria below: * \>1.75 D each eye * Difference between eyes \<1.25 D * For myopia: * Spherical equivalent \<-5.00. * Spherical equivalent difference between eyes \<1.25 D. Inclusion criteria for unilateral amblyopia: The major eligibility criteria include: * Presence of anisometropia or constant unilateral strabismus. * Best-corrected visual acuity in the amblyopic eye \<20/30; and interocular difference of best-corrected visual acuity at least two logMAR lines. * For anisometropia: * Spherical equivalent ≥ 1.00 D interocular difference * Astigmatism \>1.75 D interocular difference * For constant unilateral strabismus where spectacle prescription is indicated. Examples where spectacle prescription is indicated include esotropia caused at least in part by an accommodative component or where significant refractive error in either eye warrants spectacle prescription for improved vision.
Exclusion criteria
* History of spectacle wear * Previous treatment for amblyopia * Active amblyopia treatment planned other than spectacles at enrollment * Prior intraocular or refractive surgery * Ocular or systemic abnormalities that the examining investigator deems could impact prognosis for visual improvement. Examples could include birth history that may have affected brain development, extremely low birth weight (\<1.5 lbs), seizure disorders, cerebral palsy, optic nerve hypoplasia, cranial nerve palsy. Examples that would usually not exclude are off axis media opacity, low birth weight (2.0-3.5 lbs) without complication, mild limitation of extraocular muscle. Cognitive impairment that prohibits accurate data collection
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| visual acuity change from the baseline | 8 weeks | visual acuity change from the baseline in logMAR |
| adherence with optical treatment | 8 weeks | The adherence recorded with the microsensor will be calculated as a percentage. |
Countries
United States
Outcome results
None listed