Minor Traumatic Brain Injury, Treatment by Antiplatelet
Conditions
Keywords
S100B protein, minor traumatic brain injuries, antiplatelet therapy
Brief summary
All the patients admitted in emergency department for minor traumatized cranial, with antiplatelet therapy, can be included, after checked inclusion and non inclusions criterias. If they are agree, a blood sample for the dosage of S100b will be done. No other modification of the medical care, all patients will have tomodensitometria, according with recommendations. The aim of the study is to validate the negative predictive value of S100b in this population.
Interventions
BIOLOGICALS100B protein dosing
Patients under antiplatelet therapy and who have a minor traumatic brain injury will have a blood samples with protein S100B dosage on arrival to the emergency room and after they will have a brain scanner between 4 and 8 hours after the trauma to analyse the negative predictive value with a treshold of 0.105 μg/L
Sponsors
Poitiers University Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age \> 18 Years old * Minor traumatic brain injury measured by a Glasgow score between 13 and 15 * Antiplatelet agent therapy * Free subject without tutorship or curatorship
Exclusion criteria
* Age \< 18 years old * Glasgow score \<13 * Traumatic brain injury older than 6 hours * Patient without any social security system * Patient with renforced protection (tutorship, curatorship, …)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Brain scanner Detection of a cerebral lesion requiring a surgery or medical intervention or an hospitalisation for a patient who have serum level of S100B protein with the treshold of 0.105 μg/L | 3 hours |
Countries
France
Outcome results
None listed