Healthy Adults
Conditions
Brief summary
This study is being conducted to determine the digestibility of and available energy from pulses.
Detailed description
Previous studies have demonstrated that the metabolizable energy (energy available to the body) from tree nuts is less than predicted by the Atwater factors (the standard approach to determining calorie value of a food). The Atwater approach is over 100 years old and is inaccurate for some foods. This study will be conducted to determine the metabolizable energy from two pulses, lentils and chickpeas. The study will be a human nutrition intervention involving consumption of a controlled diet followed by collection of urine and feces.
Interventions
OTHERControl Diet
Participants will consume a diet prepared and provided by the USDA Nutrition Center. The diet will contain no pulses, legumes, or beans.
OTHERLentil Containing Diet
Participants will consume a diet prepared and provided by the USDA Nutrition Center. The diet will contain lentils.
OTHERChickpea Containing Diet
Participants will consume a diet prepared and provided by the USDA Nutrition Center. The diet will contain chickpeas.
Sponsors
USDA Beltsville Human Nutrition Research Center
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Investigator, Outcomes Assessor)
Masking description
Treatments will be color coded, and samples will be labeled only by subject number and date. Investigators and outcomes assessors will not know the treatments nor the color code until after the data analyses are complete.
Eligibility
Sex/Gender
ALL
Age
25 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
* BMI between 19 and 38 kg/m2 * Age 25 to 75 years during intervention
Exclusion criteria
* Known (self-reported) allergy or adverse reaction to study foods * Women who have given birth during the previous 12 months or who are pregnant/lactating or who plan to become pregnant during the study * History of bariatric surgery or nutrient malabsorption disease (such as celiac disease), Crohn's disease, diabetes, or metabolic disorders that may interfere with the study * History of certain cancer diagnosis or treatment in the last 3 years * Smoking or use of tobacco products in the past 6 months * Suspected or known strictures, fistulas or physiological/mechanical GI obstruction * Use of certain medications or supplements (prescription or over-the-counter) that may interfere with the study objectives, including blood thinning medications * Unable or unwilling to give informed consent or communicate with study staff * Self-report of alcohol or substance abuse within the past 12 months and/or current treatment for these problems (long-term participation in Alcoholics Anonymous is not an exclusion) * Other medical, psychiatric, or behavioral factors that in the judgment of the Principal Investigator may interfere with study participation or the ability to follow the intervention protocol
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Energy excreted in feces and urine | Cumulative from day 10-17 | Energy (units of calories) excreted in feces and urine will be determined by bomb calorimetry. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Nitrogen excreted in feces and urine | Cumulative from day 10-17, day 39-46, day 57-64 | Nitrogen (g) excreted in feces and urine will be measured. |
| Fat excreted in feces | Cumulative from day 10-17, day 39-46, day 57-64 | Fat (g) excreted in feces will be measured. |
Countries
United States
Outcome results
None listed