Sore Throat
Conditions
Brief summary
The purpose of this study is to test the hypothesis that use of preoperative nebulized lidocaine is reduced the incidence of postoperative sore throat after endotracheal intubation.
Detailed description
Adult patients undergoing video-assisted thoracic surgery (VATS) requiring double lumen tube (DLT) endotracheal intubation for one-lung ventilation (OLV) were enrolled in the study. Patients were randomized by means of computer-generated order randomization into two groups: Group C (those who received a saline solution as placebo delivered by nebulization) and Group L (those who received lidocaine delivered by nebulization). At 1, 6 and 24 h after tracheal extubation, an observer blinded to treatments evaluated the patients in terms of sore throat and hoarseness. In addition, Patients' satisfaction, intraoperative and postoperative opioid and analgesics consumption and complaints such as dysphagia, nausea and vomiting were recorded. Hemodynamic variables such as blood pressure and heart rate were also recorded.
Interventions
OTHERSaline
Effect of saline on postoperative sore throat
OTHERLidocaine
Effect of nebulized lidocaine on postoperative sore throat
Sponsors
Antalya Training and Research Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* patients undergoing video-assisted thoracic surgery requiring double lumen tube endotracheal intubation for one-lung ventilation * American Society of Anesthesiologists class 1,2 and 3 * Ability to consent
Exclusion criteria
* patients \<18 years old * body mass index (BMI) \<20 or \>35 kg/m2 * Mallampati grade 3 or 4 * mouth opening \< 3 cm * preexisting hoarseness or sore throat * coagulopathy * patient with upper respiratory tract infection
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in the incidence of postoperative sore throat | 24 hours | Sore throat was assessed using a 0-100 mm visual analog scale (VAS), where a score of 0 represents no pain and a score of 100 reflects the worst pain imaginable. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| whether the hoarseness was present or not | 24 hours | Hoarseness was defined as a change in voice quality and it was assessed by the patients themselves. The change in voice quality at any time during the observation period was defined as hoarseness was present. |
| Intraoperative opioid consumption | 60 minutes | Assessed in intraoperative period |
| Postoperative analgesic consumption | 24 hours | Assessed in postoperative period |
| Changes in mean arterial pressure | 60 minutes | Assessed every 5 minutes during the procedure |
| Changes in heart rate | 60 minutes | Assessed every 5 minutes during the procedure |
Countries
Turkey (Türkiye)
Outcome results
None listed