Anesthesia, Renal Failure Chronic, Transplant;Failure,Kidney
Conditions
Keywords
Mannitol, Dopamine, Perfusion, Renal graft donor, Anesthesia
Brief summary
Renal transplantation is now recognized as the treatment of choice for patients with end-stage renal disease. An optimum anesthetic regimen should enhance the function and perfusion of the transplanted kidney. The aim of this study is to assess & compare the effectiveness of 3 different modalities in this respect: Mannitol, Dopamine and adequate hydration.
Interventions
PROCEDUREMannitol infusion
Infusion of Mannitol 20% at a dose of 0.5 mg/kg to the renal graft donor after induction of anesthesia over 15 minutes.
PROCEDUREDopamine infusion
Infusion of Dopamine at a dose of 4 microg/kg/min to the renal graft donor after induction of anesthesia till ligation of the renal artery.
PROCEDUREAdequate hydration
Infusion of Ringer Acetate at a rate of 15 ml/kg/hr to the renal graft donor after induction of anesthesia till ligation of the renal artery.
Sponsors
Nazmy Edward Seif
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
SINGLE (Outcomes Assessor)
Intervention model description
Using computer & sealed envelope randomization, patients are assigned to receive either Mannitol \[M group; n=20\], Dopamine \[D group; n=20\] or adequate hydration \[C group; n=20\]
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* end-stage renal disease, for living-donor kidney transplantation
Exclusion criteria
* severe cardiac or hepatic dysfunction * coagulopathy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Post-operative creatinine clearance | 7 days | Post-operative creatinine clearance level of the transplanted kidney graft is measured in ml/min |
Countries
Egypt
Contacts
Primary ContactNazmy E Seif, MD
Backup ContactAhmed M Elbadawy, MD
Outcome results
None listed