Gastric Cancer
Conditions
Keywords
Lymph node metastasis, Gastric cancer
Brief summary
D2 gastrectomy is standard treatment of early gastric cancer in Japan but in other countries there is still some discord, especially in Europe and North America. Although the quantity of metastasis cancer in lymph node defines survival regardless of which country the patient is treated, the total number of lymph nodes harvested is an important factor to predict accurate staging and/or D2 gastrectomy. Both of the number total lymph nodes and the metastasis lymph node status in gastric cancer are important factors to decide each prognosis. This study evaluated the correlation between total lymph nodes retrieved and metastasis node by lymph node ratio (LNR) status to determine the recurrence rate after curative resection of gastric
Detailed description
A retrospective chart review was made of all patients who presented with gastric cancer after curative surgery resection from January 1, 1995 to December 31, 2016 in Ramathibodi Hospital.Data of metastasis node by lymph node ratio (LNR) were evaluated. The total of lymph node less than 15 and more than 15 were evaluated. The Kaplan-Meier curve estimates recurrence survival (Log-rank test). The p-value \< 0.05 is statistically significant. OBJECTIVE : The outcome of this study was evaluated lymph node ratio (LNR) status that determined by the ratio of total lymph node metastasis and the total lymph node which retrieved after performed the curative surgery and lymphadenectomy of gastric cancer. The correlation of LNR and prognosis of recurrence and survival of gastric cancer patients were evaluated and reported in this study.
Interventions
None listed
Sponsors
Mahidol University
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Gastric cancer after curative surgery resection * No received neoadjuvant therapy * Patients have tissues confirmed by Pathology * Staging used esophagogastroduodenoscopy (EGD) or imaging, including ultrasonography, Computer Tomography (CT) or Magnetic Resonance Imaging (MRI * Surgery was performed for curative intent and D2 lymphadenectomy and according from Japanese guideline for gastric cancer
Exclusion criteria
* Distant metastasis during surgery
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The correlation of lymph node ratio and survival of gastric cancer patients | 5 year | correlation of lymph node ratio and survival of gastric cancer patients.lymph node ratio was divided in to 5 ranges including 0.000-0.109, 0.110-0.209, 0.210-0.309, 0.410-0.609 and 0.610-1.000. |
| The correlation of lymph node ratio and prognosis of recurrence of gastric cancer patients | 5 year | correlation of lymph node ratio and recurrence of gastric cancer patients.lymph node ratio was divided in to 5 ranges including 0.000-0.109, 0.110-0.209, 0.210-0.309, 0.410-0.609 and 0.610-1.000. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The correlation of total of lymph node retrieved less than 15 and more than 15 nodes and survival of gastric cancer patients | 5 year | correlation of total of lymph node retrieved less than 15 and more than 15 nodes and survival of gastric cancer patients..lymph node ratio was divided in to 5 ranges including 0.000-0.109, 0.110-0.209, 0.210-0.309, 0.410-0.609 and 0.610-1.000. |
Countries
Thailand
Outcome results
None listed