Stroke, Acute
Conditions
Brief summary
Study like register with biomarkers samples for patient experiencing acute ischemic stroke, to assess clinical outcomes and different factors that may affect the clinical outcomes.
Interventions
None listed
Sponsors
Hopital Foch
Study design
Observational model
COHORT
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age 18 and older (i.e., candidates must have had their 18th birthday) * Neuroimaging demonstrates acute ischemic stroke with large vessel proximal with the use of neuro-thrombectomy devices intended to restore blood flow * No upper or lower limits of the neurological severity at baseline (NIHSS). * With or without intravenous thrombolysis * Oral informed consent (patient and/or trustworthy person) Non-inclusion Criteria: * Pregnant or breast-feeding women * Patient benefiting from a legal protection * Non-membership of a national insurance scheme
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Clinical outcome | Day 90 | modified Rankin score (mRS), score 0 to 6 with 0 = no symptoms and 6 = death. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Efficacy on revascularization (>= mTICI 2b) | Day 1 | Time to achieve TICI 2b or better revascularization |
| Efficacy on clinical outcome (mRS=0-1) | Day 90 | Rate of excellent functional outcome defined as a modified Rankin score (mRS) 0-1 |
| Efficacy on functional independence (mRS 0-2) | Day 90 | Rate of functional independence defined as a modified Rankin score 0-2 |
| Hemorrhage evaluated by imagery | Day 0 | Rate of symptomatic and asymptomatic intracerebral hemorrhage at MRI or CT scan |
| Hematoma rate | Day 1 | Rate of parenchymal hematoma 2 |
| Efficacy on reperfusion (modified Thrombolysis in Cerebral Infarction (mTICI) 2b/3) | Day 1 | Rate of complete or near complete reperfusion (modified Thrombolysis in Cerebral Infarction (mTICI) 2b/3) |
| Complication rate | Day 0 | Rate of periprocedural complications |
| ASPECT (Alberta Stroke Program Early CT score) | Day O | Measure by Axial imaging, 10-point quantitative topographic CT scan score |
| Parametric imaging | Day 0 | Diffusion, volume clinical-diffusion mismatch |
| Imaging data | Day 1 | Angiographic imaging |
| Blood sampling for research purpose | Day 0 | Search of biomarkers of stroke etiology and recovery |
| Mortality rate | Day 90 | Rate of all-cause mortality |
Countries
France
Contacts
Primary ContactElisabeth Hulier-Ammar
Outcome results
None listed