Allergic Asthma, Allergic Rhinitis, Pollution Exposure, Pollution Related Respiratory Disorder, Sleep Apnea
Conditions
Brief summary
It has been demonstrated that allergic rhinitis (AR) reduces sleep quality by some components such as nasal obstruction. Pollution and allergen exposure worsening AR, sleep quality is deteriorated. Sleep is associated to physical and mental health, alterations in sleep could explain the link between AR and work productivity diminution, impairment in daily activities or emotional problems. However, interactions between air pollution, sleep and allergic diseases are insufficiently understood. The main objective of this study is to determine the impact of pollution and pollens on sleep parameters.
Detailed description
Over 150 million people have allergic rhinitis (AR) in Europe and around 30% have uncontrolled AR during allergen exposure. It has been demonstrated that AR reduces sleep quality by some components such as nasal obstruction. Pollution and allergen exposure worsening AR, sleep quality is deteriorated. Sleep is associated to physical and mental health, alterations in sleep could explain the link between AR and work productivity diminution, impairment in daily activities or emotional problems. However, interactions between air pollution, sleep and allergic diseases are insufficiently understood. Moreover, the prevalence of OSA in patients with AR is higher than in subjects without AR. Nasal obstruction could explain the increased risk of OSA. This prospective, open study will compare sleep quality in 2 different groups: AR patients and patients without AR during the pollen season and outside the pollen season.The main objective is to determine the impact of pollution and pollens on sleep parameters for subjects with AR
Interventions
OTHERPollution exposure
Pollution exposure and sleep data will be recorded by pollution sensor and polysomnography respectively. In order to compare the variations according to the pollinisation season and the allergic rhinitis status of the patients.
Sponsors
University Hospital, Grenoble
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Intervention model description
Prospective, open study comparing sleep quality in 2 different groups: AR patients and patients without AR during the pollen season and outside the pollen season.
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* 18-65 years * Be able to use an application on a personal smartphone * Patient non treated for OSA * Be legally able to give consent * Person affiliated to social security
Exclusion criteria
\- Being unable to understand, follow objectives and methods due to cognition or language problems Subjects listed in articles L1121-5 à L1121-8: Pregnant women, feeding and parturient; subject under administrative or judicial control, persons who are protected under the act.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Impact of pollution on sleep | 6 days | Change in AHI according to the level of pollution particle matters and volatile organic compounds (VOCs) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The impact of pollution and pollens on sleep quality in patients with AR. | 6 days | Change in Pittsburgh score according to the level of pollution particle matters and volatile organic compounds (VOCs) |
| The impact of pollution on life quality | 6 days | Change in EQ-5D score according to the level of pollution particle matters and volatile organic compounds (VOCs) |
| To analyze variations in medications and impact on sleep during the pollen season and outside the pollen season. | 6 days | Change in number of medications (antiallergics and hypnotics) according to the level of pollution particle matters and volatile organic compounds (VOCs) |
Countries
France
Outcome results
None listed