Preserving Left Colonic Artery During Radical Resection of Rectal Cancer

A Clinical Cohort Study on the Effect of Preserving Left Colonic Artery During Radical Resection of Rectal Cancer on Anastomotic Leakage and Oncology Efficacy

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03776370

Enrollment

200

Registered

2018-12-14

Start date

2018-12-01

Completion date

2022-01-01

Last updated

2022-05-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative Complications, Proteinosis

Keywords

rectal cancer, Postoperative Complications, Preserve the left colonic artery

Brief summary

To evaluate the feasibility and clinical significance of preserving left colonic artery in rectal cancer surgery.The investigators will focus on the effect of preserving left colonic artery during radical resection of rectal cancer on anastomotic leakage and oncology efficacy.

Detailed description

The investigators performed three-dimensional (3D) reconstruction to investigate the vascular anatomy, including the inferior mesenteric artery (IMA) and left colic artery (LCA),to help make pre-operative strategies of rectal cancer surgery.The investigators will preserving the left colonic artery during rectal cancer surgery and evaluate its feasibility and clinical significance.The investigators will focus on the effect of preserving left colonic artery during radical resection of rectal cancer on anastomotic leakage and oncology efficacy.

Interventions

PROCEDUREPreserve the left colonic artery

Preservation of left colonic artery in rectal cancer surgery.

PROCEDUREThe left colonic artery is not preserved

The left colonic artery was dissected in rectal cancer surgery.

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

1. Pathological biopsy confirmed adenocarcinoma of the rectum； 2. Preoperative assessment of tolerance to surgery without major organ dysfunction； 3. Patients must be able to understand and voluntarily sign written informed consent； 4. The surgical method is laparoscopic or robotic anterior rectal cancer resection.

Exclusion criteria

1. The patient cannot tolerate the operation； 2. Refusal to sign informed consent； 3. Patients with distant metastasis of rectal cancer； 4. The surgical method was changed to miles or Hartman; 5. Unable to complete the follow - up

Design outcomes

Primary

Measure	Time frame	Description
The incidence of postoperative anastomotic leakage was compared between the two groups.	Within 30 days after surgery	The incidence of anastomotic leakage within 30 days after surgery was compared between the intervention group and the control group.
The distant metastasis rates of rectal cancer between the two groups were compared.	Two years after surgery	The incidence of distant metastasis rectal cancer within two years after surgery was compared between the intervention group and the control group.
The local recurrence rates of rectal cancer between the two groups were compared.	Two years after surgery	The incidence of local recurrence rectal cancer within two years after surgery was compared between the intervention group and the control group.
The five-year survival rates of rectal cancer between the two groups were compared.	Five years after surgery	The 5-year survival rates of rectal cancer in the intervention group and the control group were compared.

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 12, 2026