Insulin Resistance
Conditions
Keywords
skeletal muscle, muscle fatigue, ion handling
Brief summary
To investigate the role of ATP sensitive K+ potassium channels and the Na+/K+ pump in the development of fatigue in healthy and in insulin resistant subjects.
Interventions
DRUGPlacebo
placebo tablet
DRUGNicorandil
20 mg nicorandil (Ikorel, Sanofi Winthrop Industrie; NIC)
Sponsors
University of Copenhagen
Study design
Allocation
RANDOMIZED
Intervention model
SEQUENTIAL
Primary purpose
BASIC_SCIENCE
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
MALE
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* Non smokers * HbA1c \<38 mmol/mol (\<5.7%), HOMA-IR \> 1.7 (insulin resistant) * VO2max \<40 ml/kg/min (insulin resistant), 45-55 ml/kg/m2 (healthy) * BMI \>26 kg/m2 (insulin resistant), 19-26 kg/m2 (healthy)
Exclusion criteria
* Use of antidiabetic medication or any other medication deemed to interfere with study outcomes * Allergy towards Nicorandil * Chronic disease other than type 2 diabetes deemed to interfere with study outcomes * Excessive alcohol consumption (\>14 units/week) * Abnormal ECG
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Extracellular potassium concentration meassured with microdialysis | Changes in potassium handling from the placebo experimental day compared to the experimental days with Nicorandil ingestion with 14 days between each experimental day. Timeframe pr. subject approx. 6 weeks | Interstitial potassium |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Performance (time to exhaustion) during knee extensor exercise | Changes in performance during the placebo experimental day compared to the experimental days with Nicorandil ingestion with 14 days between each experimental day. Timeframe pr. subject approx. 6 weeks. | Muscle exercise tolerance |
Countries
Denmark
Outcome results
None listed