Cesarean Section, Dexmedetomidine, Spinal Anesthesia
Conditions
Keywords
Cesarean Section, Intrathecal Dexmedetomidine
Brief summary
The aim of this study is to evaluate the effectiveness of low dose scheme with dexmedetomidine as an adjuvant. Taking in consideration optimum intraoperative surgical conditions, best post-operative pain free experience, and more stable hemodynamic.
Interventions
DRUGDexmedetomidine
10μg dexmedetomidine will be added to the injectate to be injected intrathecally
Sponsors
Menoufia University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* Full-term pregnant women * Singleton gestation * American Society of Anaesthesiologists (ASA) physical status classes II and I
Exclusion criteria
* Preterm pregnancy (\<37 wks. gestation) * Multiple gestation * Cardiovascular disease (e.g., preeclampsia, hypertension) and the use of antihypertensive medications * Asthma and allergy to non-steroidal anti-inflammatory drugs * Conditions that prevent spinal anaesthesia * Failed spinal block and conversion to general anaesthesia * A history of established chronic pain * Drug addiction * A psychiatric disorder * Inability to communicate effectively
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Density of motor and sensory blockade | Intraoperative |
| Haemodynamic stability and total doses of IV fluids and vasopressors | Intraoperative |
| Time to first postoperative rescue analgesic request | 24 hour |
Secondary
| Measure | Time frame |
|---|---|
| The time to two sensory block segment regression | Intraoperative and 24 hour |
| Degree and duration of motor block | Intraoperative and 24 hour |
| Intraoperative analgesic supplementation during operation | Intraoperative |
| Postoperative pain scores for 24 hours | 24 hour |
| The intraoperative patient and surgeon satisfaction (successful delivery) | Intraoperative |
| Intraoperative and postoperative sedation scores | Intraoperative and 24 hour |
| Incidence of side effects: nausea, vomiting, shivering, pruritus, respiratory depression, and desaturation. | Intraoperative and 24 hour |
| Hospital in stay | 24 hour |
| Time to S1 level sensory regression | Intraoperative and 24 hour |
| Frequency and total dose of postoperative analgesics | 24 hour |
| The peak sensory level of block | Intraoperative |
| Time from intrathecal injection to peak sensory block level | Intraoperative |
Countries
Egypt
Outcome results
None listed