Community-acquired Pneumonia
Conditions
Keywords
pneumonia, community acquired pneumonia, protein, lean body mass, weight loss, readmission, infection
Brief summary
The purpose of this clinical trial is to reduce the patient's loss of lean body mass by protein supplementation during hospitalization and 60 days after hospital discharge. Also, the study aims to reduce the risk of readmission to the hospital due to relapse or complications and thereby improving the overall health for the patients. The intervention group will receive protein supplementation during hospitalization and after discharge, while the control group will continue their normal diet.
Detailed description
Infections are globally the biggest cause of mortality. In Denmark community acquired pneumonia is one of the most common causes for infections in patients. Mortality in pneumonia has been stable high over the past 10 years. Therefore, it is relevant to look at improving the prognosis of these patients. After a longer period of hospitalization, patients generally have a poor condition with loss of body weight and lean body mass. Hereafter, patients must often undergo a longterm rehabilitation period and they become inactive and fatigue. This is a threat for the patients, due to the fact that there is a higher risk of complications and readmissions. Proteins are the body's building blocks. Thus, supplementing patients with a daily higher protein content, it is believed to reduce their loss of lean body mass, and thereby reduce the total loss of body weight as well. Protein supplementation together with vitamin- and mineral supplementation is thought to improve all these health risk markers for the patients. Methods: Inclusion: 40 men and women \>60 years hospitalized with community acquired pneumonia Intervention: The patients will be randomized to either the control- or intervention group. They will receive the same treatment and care, the only difference is that the patients in the intervention group will receive protein- and vitamin supplementation.
Interventions
DIETARY_SUPPLEMENTProtein and vitamin supplementation
The intervention group will receive 1.5 g protein/kilo/day during hospitalization and a standard dose of 27 g protein/day in 60 days after discharged together with a daily dose of vitamin/mineral supplement
Sponsors
Nordsjaellands Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
Randomized to intervention or control arm
Eligibility
Sex/Gender
ALL
Age
60 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Hospitalized patients with community acquired pneumonia * \>60 years * Patients who are able to speak and understand Danish
Exclusion criteria
* Patients with hospitalized acquired pneumonia * Patients with septic shock * Patients with an active cancer and in cancer treatment * Patients in dialysis * ICU patients * Patients unable or unwilling to give informed consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Loss of Lean Body Mass | Change from Baseline lean body mass until 2 months after discharged | Loss of lean body mass measured by bioimpedance |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Loss of Body weight | Change from Baseline weight until 2 months after discharged | Loss of body weight measured by weight scale |
| Readmissions | Up to 6 months | Number of readmissions |
| Length of hospital stay between the two groups | From admission until discharge (an average of 5 days) | Number of days |
| Quality of life measured by units on a scale | Change in individual experiences regards to quality of life from Baseline until 2 months after discharged | Quality of life measured by units on a scale |
| Normal daily living function | Change in physical condition from Baseline until 2 months after discharged | Normal daily living function measured by units on a scale |
Countries
Denmark
Outcome results
None listed