Fracture of Lower Limb, Knee Osteoarthritis, Necrosis of Femoral Head
Conditions
Brief summary
Periperative neurocognitive disorder(PND) is consistently associated with increased morbidity and mortality, but its mechanisms remain unclear. Moreover, valid biomarkers for the prediction or diagnosis of the development of delayed neurocognitive recovery in aged patients have not been identified so far. The purpose of this study is trying to find the functional MRI marker of PND.
Interventions
None listed
Sponsors
RenJi Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
60 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age ≥ 60 years * Spoke proficient Chinese * Selected to lower limb osteopathic surgery * Informed consent signed by the patient * Underwent general anesthesia
Exclusion criteria
* Existing cerebral disease, or have a history of neurological and psychiatric diseases including AD, stroke, and psychosis * Existing cognitive impairment as evidenced by Mini-Mental State Examination scores below 24 * Several audition or vision disorder * With standard contraindications to MRI examinations * Unwillingness to comply with the protocol or procedures.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| MRI markers of PND before 7th day after surgery | From the day before surgery to the 7th day after surgery | To analysis the association of volume of hippocampus measured by MRI and the occurrence of PND identified at the 7th day after surgery |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| MRI markers of PND before 12 month after surgery | From the 7th day after surgery to 12 month after surgery | To analysis the association of volume of hippocampus measured by MRI and the occurrence of PND identified at the 12 months after surgery |
Countries
China
Contacts
Primary ContactDiansan Su, Dr.
Outcome results
None listed