Dyslipidemias
Conditions
Brief summary
The investigators conduct a randomized, double-blind, placebo-controlled study to investigate the effects of the Ulmus Macrocarpa Hance extract on lipid profile in adults with dyslipidemia for 12 weeks.
Detailed description
Previous another our study have indicated that Ulmus Macrocarpa Hance extract (UMH) may have the ability to decrease blood cholesterol. Therefore, the investigators conduct a randomized, double-blind, placebo-controlled study to investigate the effects of the UMH on lipid profile in adults with dyslipidemia; the safety of the compound are also evaluate. The Investigators examine total cholesterol, HDL-cholesterol, triglyceridemia, LDL-cholesterol, and other biochemical parameters at baseline, as well as after 6 and 12 weeks of intervention. Eighty adults were administered either 500 mg of UMH or a placebo each day for 12 weeks;
Interventions
DIETARY_SUPPLEMENTPlacebo
Starch placebo 500 mg/day for 12 weeks
DIETARY_SUPPLEMENTUMH extract
Schisandra chinensis extract 500 mg/day for 12 weeks
Sponsors
Sang Yeoup Lee
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
20 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
* LDL cholesterol ranging from 130 to 190 mg/dL
Exclusion criteria
* Abnormal liver or renal function (i.e., serum aminotransferase activity \> 80 IU/L and serum creatinine concentrations \> 1.2 mg/dL) * Diabetes (diagnosed clinically or fasting glucose level \> 126 mg/dL) * History of ischemic heart disease or cerebrovascular disease * Uncontrolled hypertension * History of serious cardiac disease such as angina or myocardial infarction * History of gastrectomy * History of medication for psychiatric disease * Administration of oriental medicine including herbs within the past 4 weeks
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| LDL cholesterol | 12 weeks | LDL cholesterol |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Total cholesterol | 12 weeks | Total cholesterol |
| Triglyceride | 12 weeks | Triglyceride |
| HDL cholesterol | 12 weeks | HDL cholesterol |
Countries
South Korea
Outcome results
None listed