Appendicitis
Conditions
Brief summary
Surgical site infection is a common problem after open appendectomy. Irrigation of the surgical wound by topical antibiotics has been devised as a measure to reduce the incidence of wound infection. The present trial aims to assess the efficacy of layer-by-layer wound irrigation with gentamicin-saline solution in prevention of superficial surgical site infection after open appendectomy for acute uncomplicated appendicitis.
Interventions
PROCEDUREIrrigation
upon closure of the peritoneum gentamicin-saline solution (160 mg of gentamicin in 400 ml of normal saline 0.9%) will be used for irrigation of every layer of the wound before its closure
Sponsors
Mansoura University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
16 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Adult patients of both genders aging between 18 and 65 years who present with acute appendicitis. * Patients with perforated appendicitis will be also included.
Exclusion criteria
* Patients with appendicular mass, appendicular abscess, generalized peritonitis. * Patients with other causes of acute abdomen as revealed intraoperatively. * Patients taking long course of steroid therapy or immunosuppressive treatment, * Patients unwilling to participate in the trial.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Surgical site infection | 2 months after surgery | The incidence of superficial site infection as detected by clinical examination on follow-up |
Countries
Egypt
Outcome results
None listed