Antimicrobial Effect, High Caries Risk Patients, Patient Satisfaction to Taste, Salivary pH
Conditions
Brief summary
This trial is to test the antibacterial effect of Guava leaves extract mouth wash compared to Chlorhexidine mouth wash in high caries risk patients. Also salivary pH and patient satisfaction to taste will also be tested.
Detailed description
This study is conducted to evaluate the effect of Guava leaves extract mouth wash on anti-bacterial activity against streptococcus mutans, salivary pH and patient satisfaction to taste compared to Chlorhexidine mouth wash. P: Population with high caries risk patients I: Intervention by Guava leaves extract mouthwash C: Control is Chlorhexidine mouthwash O1: The primary outcome is antibacterial activity. O2: The secondary outcome is salivary pH O3: The tertiary outcome is patient satisfaction to taste
Interventions
DRUGGuava leaves extract
Natural product : The leaves of the guava tree are full of antioxidants, anti-inflammatory agents, antibacterials, and even tannins that can have significant health benefits, from treating stomach troubles to chronic diseases like cancer •
DRUGChlorhexidine
chemical agent used as a mouthwash against cariogenic bacteria. considered the gold standard
Sponsors
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
1. High caries risk patients 2. 18-50 years 3. Healthy cooperative patients 4. Males or Females
Exclusion criteria
1. Medically compromised patients 2. Patients with any systemic disease that might affect the salivary flow 3. Allergy to any of the ingredients 4. Patients with physical limitations that might affect normal tooth brushing and mouth rinsing 5. Presence of intraoral infections 6. Currently using any mouth rinse 7. Smokers 8. Use of antibiotics in the previous 30 days
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Anti-bacterial effect against streptococcus mutans | 3 months | Antimicrobial effect against streptococcus mutans: saliva samples collected and total bacterial count measured after agar plates incubating, expressed in colony forming units |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Salivary pH | 3 months | Saliva samples pH will be measured using digital pH meter to evaluate its efficacy in preventing the action of acidogenic bacteria in high caries risk patients. It displays numerical value. |
Other
| Measure | Time frame | Description |
|---|---|---|
| Patient satisfaction to taste: questionnaire | 3 months | The patient will fill a questionnaire to assess patient satisfaction to taste after usage of the mouthwash. Nominal answers |
Contacts
Primary ContactEngy MM Kassem, Master's degree
Backup ContactMohamed A Khairy, PhD
Outcome results
None listed