Defining the Sympathetic Skin Response of Migraineurs in the Facial Area

Defining the Sympathetic Skin Response of Migraineurs in the Facial Area During the Interictal State: Comparison of Migraine Patients Who Suffer Dominant Left/Right/Bilateral Pain.

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03772860

Enrollment

Registered

2018-12-11

Start date

2018-12-31

Completion date

2019-12-31

Last updated

2018-12-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Migraine Disorders

Brief summary

The aim of this study is to define the sympathetic skin response of migraineurs in the facial area. This will be achieved by exposing healthy volunteers and migraine patients to various stress stimuli (pain, visual stimulation, auditory stimulation and a mathematical challenge), and recording sympathetic skin response in the facial area.

Interventions

OTHERPain stimulation

Pain will be simulated with an electric shock 25 mlAMP over the median nerve

OTHERVisual stimulation

Visual stimulation will be performed by a flicker of light on a computer screen at 15 Hrz for 0.3 seconds

OTHERAuditory stimulation

Auditory stimulation will be delivered through headphones with a sound at 500 Hrz at 85 decibels for 0.3 seconds

OTHERMental stress

A mathematical challenge will be displayed on a computer screen that must be quickly solved

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Healthy volunteers with no history of any kind of recurrent headache * Migraine patients according to ICH3 criteria * Migraine patients with more than 1 attack per month

Exclusion criteria

* Patients with other heart or neurologic diseases * Patients with hearing or visual decline * Patients taking medication that effects the sympathetic system (except those taking beta blockers for migraine treatment)

Design outcomes

Primary

Measure	Time frame	Description
Defining sympathetic skin response in migraineurs	One year	Outcome will be presented as mean sympathetic response values for all the different stimuli and then separately for each stimuli

Secondary

Measure	Time frame	Description
Defining differences between sympathetic skin response in migraineurs	One year	Outcome will be presented as mean sympathetic response values for all the different stimuli and then separately for each stimuli

Countries

Israel

Contacts

Primary ContactErel Domany, MD

erel.domany@gmail.com972-52-6134235

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026