Skin and Subcutaneous Tissue Disorders
Conditions
Brief summary
As the quality of life improves, people are seeking to look as young as they feel. Ginkgo biloba (GB) and Pomegranate (PG) extract can be used to create efficacious topical anti-aging products. GB & PG are now widely used in research and clinical trials on age-associated diseases, for example, skin aging, brain dysfunction, cardiovascular system diseases, carcinogen metabolism. The investigator's aim is to formulate a topical cream in the form (O/W or W/O emulsion) formulation, containing GB as an anti-aging formulation for the public.
Detailed description
In this study, a vanishing cream will be prepared by reaction of a stearic acid with alkali (NaOH) to form stearate soap. Then the GB extract will be added to the final form. The formulated cream will be characterized for identifying the type of emulsion, calibration curve for GB, drug content, irritation to skin, homogeneity test, pH, FT-IR test, ex vivo studies, physical stability, and human application. Finally, a 9-questions questionnaire was published using Google forms for the human volunteers.
Interventions
DRUGCream Base
The formulated dosage form without ginkgo biloba or pomegranate will be applied to the 30 aging people who are suffering from wrinkles in the skin male and female. Typically, will be applied on two groups, one man (Group 0a) and one woman were (Group 0b) which they will be used plain cream.
DRUGPomegrante and Ginkgo biloba group
The extracts of ginkgo biloba and Pomegranate as formulated in topical dosage form will be applied to the 30 aging people who are suffering from wrinkles in the skin male and female. Formulated cream will be applied on two groups, one man (Group Ia)and one woman (Group Ib).
Sponsors
Ahmed A. H. Abdellatif
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
50 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* Clinical diagnosis of aging shape * Follow up and collect data for a local and systemic activity of Ginkgo Biloba and Pomegranate * The skin should be not injured as the cream can be easily applied * Systemic oral capsule Ginkgo Biloba and Pomegranate can be also given to enhance the activity as anti-aging activity
Exclusion criteria
* Insulin-dependent diabetes * Hypertension disease * Skin wound
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Measurement of ant-aging activity of Pomegranate and Ginkgo biloba | Three months | The crow's feet wrinkle of 17 volunteers will be measured compared to the control group. The significant results will measure the decrease in the depths of deep furrows for groups treated with Pomegranate and Ginkgo biloba over a three months period. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Stable topical anti-aging products for long life shelf storage | Six months | Stability test will be studied for dosage forms. The test will be carried out by standing the products on shelf life for six months. The stability test will be recorded using high-performance liquid chromatography each thee days. |
Countries
Egypt, Saudi Arabia
Contacts
Primary ContactAhmed AH Abdellatif, Ph.D.
Outcome results
None listed