Intracranial Germ Cell Tumor
Conditions
Keywords
fMRI, DTI, Intracranial Germ cell tumor, Basal ganglia
Brief summary
BOLD-fMRI and DTI scans are performed to patients with germ cell tumors in the basal ganglia before and after treatments. The changes of the MRI and muscle strength of patients during treatments are evaluated, and the association between these two are investigated.
Detailed description
Primary intracranial germ cell tumors are a specific entity of brain tumors with a variety of histological types and different degrees of malignancy. Intracranial GCTs make up 11.2% - 15.3% of primary intracranial tumors in Asian children compared with 3.6% in the US. And tumors located at the basal ganglia is much rarer. The investigators realize that most of patients with tumors at this location are involved with motor disfunction. And after treatments, some patients get relieved dramatically, but some others failed to get similar outcomes. To better understand the mechanism causing this difference of treatment outcomes, the investigators perform BOLD-fMRI and DTI scans to patients with germ cell tumors in the basal ganglia before and after treatments. The changes of the fMRI and muscle strength of patients during treatments are evaluated, and the association between these two are investigated.
Interventions
RADIATIONradiotherapy
whole brain with/without spinal cord
Sponsors
Beijing Neurosurgical Institute
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
3 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. age ≥3 years; 2. no history of brain radiotherapy; 3. no other known cause of movement and cognitive impairment; 4. no contraindications to the magnetic resonance imaging (MRI) scan;
Exclusion criteria
1. patients can not tolerate MR scan; 2. head motion is greater than 3 mm during functional MRI scanning.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes of brain networks measured by BOLD-fMRI after treatments. | The fMRI scans are performed: (1) before treatments in one week, (2) before radiotherapy in one week, (3) after radiotherapy in one week, (4) one year after radiotherapy. | The brain networks during treatments are compared by functional connectivity. |
| Changes of white matter fibers measured by DTI after treatments. | The DTI scans are performed along with the fMRI scans. | The white matter fibers damaged by tumor are evaluated by FA and MD value. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Changes of muscle strength after treatments. | The muscle strength evaluation are performed at the same day before the fMRI scans. | The limb muscle strength of patients are evaluated with the Medical Research Council (MRC) scale for muscle strength (grade 0-5). |
Countries
China
Contacts
Primary ContactXiaoguang Qiu, M.D.
Backup ContactShuai Liu, M.D.
Outcome results
None listed