Cerebral Stroke, Dysarthria, Dysphagia, Spinocerebellar Ataxia, Stroke
Conditions
Keywords
speech, swallowing, rehabilitation, stroke, deglutition, dysphagia, dysarthria, laryngeal, ataxia
Brief summary
This study will test laryngeal adaptation in speech and swallowing function in healthy adults, in patients with cerebral stroke, and in patients with spinocerebellar ataxia type 6. The findings from this proposal will be the first step toward implementing rehabilitation techniques that help patients to prevent speech and swallowing errors before they occur.
Interventions
DEVICEIntermittent Perturbation to Continuous Perturbation
Manipulate the Movement Planning Period (MPP), by interrupting sensory predictions by removing e-stim during the inter-trial interval (Intermittent Perturbation), followed by a washout/de-adaptation period.
DEVICEContinuous Perturbation to Intermittent Perturbation
Manipulate the Movement Planning Period (MPP), by keep sensory input about the perturbation constant by maintaining e-stim during the inter-trial interval.
Sponsors
National Institute on Deafness and Other Communication Disorders (NIDCD)
National Institutes of Health (NIH)
University of Florida
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
A cross-sectional study design will be used to examine laryngeal adaptation across all study groups.
Eligibility
Sex/Gender
ALL
Age
21 Years to 100 Years
Healthy volunteers
Yes
Inclusion criteria
Patient Inclusion Criteria: All stroke and ataxia Ataxia * DNA diagnosis of SCA6 and phenotype consistent with the DNA diagnosis * No recessive, X-linked or mitochondrial Stroke * Bilateral or unilateral middle cerebral artery (MCA) stroke * No structural abnormalities (i.e. nodules) * Dysphagia involving laryngeal dysfunction Stroke and ataxia with speech and swallowing disorders * no structural abnormalities * dysphagia involving laryngeal dysfunction Patient
Exclusion criteria
* Montreal Cognitive Assess. \<24 * Moderate to severe hearing loss * Barium allergy * Other confounding speech disorder (i.e. stuttering) * Chemo-radiation, surgical head and neck treatment * Smoking Hx in the past 5 yrs or \>5 years at any one time * Twenty one years of age or older * Breathing disorders or diseases
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Laryngeal Adaptation in Speech | Day 1 | To differentiate laryngeal adaptation during speech among cerebral stroke, SCA6, and healthy controls when vocal loudness is perturbed with expiratory loading. |
| Laryngeal Adaptation in Swallowing | Day 1 | To differentiate laryngeal adaptation among cerebral stroke, SCA6, and healthy controls when swallowing is perturbed with neck surface electrical stimulation to restrict laryngeal elevation. |
Outcome results
None listed