Psoriasis
Conditions
Brief summary
This study will ascertain approximately 150 subjects, which will include pediatric psoriasis patients diagnosed before age 12, parents not affected by psoriasis, and if a family history is indicated, up to third-degree family members. Saliva (or buccal swabs in the case of infants) will be obtained for DNA isolation.
Interventions
OTHERSaliva or buccal sample
Saliva or buccal sample
Sponsors
National Psoriasis Foundation
Icahn School of Medicine at Mount Sinai
Northwestern University
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Patients (of any age) who developed psoriasis before 12 years of age and who have no family history of psoriasis in either parent. * Parents of patients who developed psoriasis before 12 years of age * Up to third-degree family members (first cousin, grandparent, great-grandparent) with or without psoriasis, if family history is indicated.
Exclusion criteria
* Patients, parents, and other family member unable to give a saliva or buccal swab sample. * Patients, parents, and other family member unable to give written informed consent.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| CARD14 mutations | one year | The number of pathogenic mutations identified in CARD14 in a pediatric psoriasis cohort |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| De novo mutations | one year | The number of candidate psoriasis genes through the identification of de novo mutations in moderate-to-severe pediatric cases who require systemic intervention. |
Countries
United States
Outcome results
None listed