Amblyopia
Conditions
Brief summary
Amblyopia affects 3% of the children and is caused by strabismus, anisometropia or both. Standard treatment is glasses and patching therapy. From North-America, behavioural training, i.e. dichoptic training, perceptual learning and video gaming, has become increasingly popular to improve visual acuity not only in children but also in adults. In this study we aim to compare the standard occlusion therapy with dichoptic video gaming.
Detailed description
Amblyopia affects 3% of the children and is caused by strabismus, anisometropia or both. The standard treatment is glasses and patching therapy. From North-America, behavioural training, i.e. dichoptic training, perceptual learning and video gaming, has become increasingly popular. The rationale behind these games is by using dichoptic stimulation, with the contrast of the stimuli presented to the good eye reduced to match the appearance of the same stimuli when shown to the amblyopic eye, suppression can be alleviated. The many studies now conducted, demonstrate improvement in visual acuity with the games, the effect however is limited, but the rate of improvement is higher. In these studies, prescribed patching-time was compared to realised game-time. We have demonstrated in multiple studies that electronically measured compliance is low: on average only 50%. In this study we aim to compare the effect of patching therapy, using the ODM to objectively measure compliance, with the effect of a novel dichoptic action video game in children as well as in adults. In addition, the adult participants will undergo fMRI scans to document any changes in the visual cortex before and after either therapy.
Interventions
OTHERDichoptic video game therapy
Dichoptic video gaming for 1 hour per week, viewed through the Oculus Rift.
OTHEROcclusion therapy
Occlusion therapy for 2 hours per day, 7 days a week
Sponsors
Lijf & Leven
ODAS Stichting
Uitzicht
University of Applied Sciences Utrecht
Erasmus Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Caregiver)
Masking description
The research orthoptist that does the orthoptic examinations is masked to the randomization.
Intervention model description
Participants are randomized to either the standard patching therapy or the dichoptic video game therapy.
Eligibility
Sex/Gender
ALL
Age
4 Years to 55 Years
Healthy volunteers
No
Inclusion criteria
* Amblyopia; an interocular difference in visual acuity of at least 2 logMAR lines.
Exclusion criteria
* A non-comitant or large angle constant strabismus \>30Prism Dioptres, a neurological disorder, nystagmus, other eye disorders and diminished acuity due to medication, brain damage or trauma.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Visual Acuity improvement | 24 weeks | Visual Acuity improvement (logMAR units/time period) in children with amblyopia treated with patching therapy vs dichoptic video gaming |
Countries
Netherlands
Contacts
Primary ContactSjoukje E Loudon, MD, PhD
Backup ContactAveen Kadhum, Bsc
Outcome results
None listed