Diabetes Mellitus, Type 2, Pediatric Obesity
Conditions
Brief summary
The objective of this study was to investigate the association of irisin with inflammatory markers as well with metabolic and anthropometric parameters in children and adolescents with type 2 diabetes mellitus compared with healthy controls.
Detailed description
Mexican children and adolescents previously diagnosed with type 2 diabetes mellitus according to the American Diabetes Association (ADA) criteria were recruited and compared to healthy controls. The participants will undergo: * vital signs measurement (systolic and diastolic blood pressure, heart rate, respiratory rate) * anthropometric variables measurement (BMI, weight, waist circumference, hip circumference, body fat %) * laboratory studies: glucose, triglycerides, HDL-c, C reactive protein, irisin After statistical analyses the investigators will compare the relationship of irisin and the inflammatory profile and the anthropometric parameters of diabetic patients versus lean controls.
Interventions
None listed
Sponsors
Instituto Tecnologico y de Estudios Superiores de Monterey
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
6 Years to 17 Years
Inclusion criteria
• Have been previously diagnosed with T2DM according to the American Diabetes Association (ADA) criteria . Healthy controls were required to have: * Normal weight according to the Centers for Disease Control and Prevention (CDC) criteria. * No metabolic abnormalities on blood samples * No previously diagnosed cardiometabolic diseases * Not been using antihypertensive, lipid or glucose lowering medications
Exclusion criteria
* Disapproval by the children's physician due to any at-risk medical condition known by the parents * Use of drugs for high blood pressure, hyperglycemia, or dyslipidemia
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Correlation of irisin levels and anthropometric parameters in children with type 2 diabetes mellitus (T2DM) | 1 day | Correlation of irisin levels and anthropometric parameters in children with T2DM |
| Correlation of irisin levels and anthropometric parameters in healthy control children | 1 day | Correlation of irisin levels and anthropometric parameters in healthy control children |
| Correlation of irisin levels and cytokines levels in children with T2DM | 1 day | Correlation of irisin levels and cytokines levels in children with T2DM |
| Correlation of irisin levels and C reactive protein levels in healthy control children | 1 day | Correlation of irisin levels and C reactive protein levels in healthy control children |
| Comparison between groups | 1 day | Compare the correlations of irisin woth anthropometric parameters and INFLAMMATORY MARKERSbetween children diagnosed with T2DM and healthy controls |
Countries
Mexico
Outcome results
None listed