Blood Transfusion Complication, Oxidative Stress
Conditions
Brief summary
Primary aim is to evaluate the effect of blood transfusion on oxidant-antioxidant status in premature neonates. Secondary aim is to assess the effect of the age of transfused red blood cells on the biological markers of oxidative stress.
Detailed description
Oxidant-antioxidant status will be assessed by measuring total antioxidant capacity (TAC) and malondialdehyde (MDA), as well as antioxidant minerals, in 65 term and near-term neonates.
Interventions
BIOLOGICALpacked red blood cells transfusion
packed red blood cells transfusion
Sponsors
Rania Ali El-Farrash
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
HEALTH_SERVICES_RESEARCH
Masking
TRIPLE (Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
35 Weeks to 37 Weeks
Healthy volunteers
No
Inclusion criteria
* Premature neonates ≤36 weeks in need for blood transfusion.
Exclusion criteria
* Critically ill neonates.(perinatal asphaxia,on high setting mechanical ventilation,different types of shock eg ;septic shock and major congenital anomalies) * Extremely low birth weight neonates(\<1000gm birth weight ) * Recipient of blood transfusion before enrollment in the study. * Neonates planned for exchange transfusion .
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| malondialdehyde | 2-3 hours posttransfusion | MDA |
| total antioxidant capacity | 2-3 hours posttransfusion | TAC |
| serum Copper | 2-3 hours posttransfusion | s.Cu |
| serum Zinc | 2-3 hours posttransfusion | s.Zn |
| serum magnesium | 2-3 hours posttransfusion | s.Mg |
| serum iron | 2-3 hours posttransfusion | s.Fe |
| serum Calcium | 2-3 hours posttransfusion | s.Ca |
Countries
Egypt
Outcome results
None listed