Anemia, Critical Illness
Conditions
Keywords
transfusion, intensive care medicine, 90-day mortality
Brief summary
Anemia is common in intensive care unit (ICU) patients and often appears early in the ICU course. The optimal management red blood cells RBC transfusion in critically ill patients remains controversial and clinical studies in this field have usually been based on transfusion thresholds. In the TRICC Trial, patients assigned to a restrictive transfusion strategy (transfusion if Hb\<7 g/dL) had similar mortality to patients transfused if Hb\<10 g/dL. Notably, none of the large RCT tried to focus on a personalize RBC transfusion protocol, i.e. a transfusion protocol which address the individual need for transfusion basing on physiological approach. We therefore hypothesized that patients with high extraction of oxygen could benefit more of RBCs transfusion regardless their hemoglobin levels.
Interventions
None listed
Sponsors
Università degli Studi di Ferrara
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Hemoglobin level \<10 g/dL during the first 72 hours of ICU
Exclusion criteria
* Acute bleeding * Hemoglobin level less than 7 g/dL
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| 90-day mortality | after 90 days from study enrollment | mortality |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Acute kidney injury | 7 days after study inclusion | Occurence of acute kidney injury according to KDIGO 2012 guidelines |
| Length of ICU stay | from ICU admission to discharge, up to 8 weeks | — |
| Variation in Sequential Organ Failure Assessment (SOFA) score | 5 days | daily variation in SOFA score (0-24 points scale with higher values indicating worst conditions) |
| Days of vasopressor | 28 days after study inclusion | Need for vasopressor |
Countries
Italy
Outcome results
None listed