Cannabis Use, Tobacco Use
Conditions
Brief summary
Cannabis smokers who also smoke tobacco cigarettes have markedly higher rates of cannabis relapse relative to those who do not use tobacco. There is a clear need to develop and evaluate interventions for dual tobacco and cannabis users. The investigators of this study have previously shown that the co-use of tobacco cigarettes contributes to the maintenance of daily cannabis use, and that age of cigarette onset is a critical predictor of treatment outcome. Short-term tobacco cessation may suffice in altering cannabis relapse rates in later-onset cigarette smokers, while a longer period of tobacco cessation may be needed for earlier-onset smokers. In the current study, a human laboratory model will be utilized to determine whether cannabis relapse varies as a function of tobacco cessation duration and age of tobacco use onset.
Interventions
BEHAVIORAL7 days of Tobacco Cessation
Participants will be randomly assigned to 7 days of tobacco cessation.
BEHAVIORAL21 days of Tobacco Cessation
Participants will be randomly assigned to 21 days of tobacco cessation.
DRUGCannabis
Participants will receive cannabis.
Sponsors
New York State Psychiatric Institute
National Institute on Drug Abuse (NIDA)
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Masking description
Research staff will be blind to the age of tobacco onset condition.
Intervention model description
The effects of 7- and 21-days of tobacco cessation on cannabis relapse in daily cigarette-smoking, cannabis smokers will be compared, with half the participants in each group initiating tobacco cigarette smoking early (\<16 years) and the other half later (\>=16 years).
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* Males and non-pregnant females aged 18-60 years old * Use cannabis * Smoke tobacco cigarettes * Medically and psychologically healthy
Exclusion criteria
* Regular drug use other than cannabis * Current pregnancy/lactation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cannabis self-administration | During 9-day inpatient phase | Number of cannabis cigarettes participant chooses to smoke. |
Countries
United States
Outcome results
None listed