Cognitive Decline
Conditions
Brief summary
postoperative cognitive decline is a common and deleterious complication in aged patients.The link between inflammation and postoperative cognitive decline has also been reported.However,the link between SOD1，SOD2，Osteopontin， Kallikrein-6，and Contactin-1 and postoperative cognitive decline is unknown. In this project ,investigators examine the relationship between 5 cytokines measured at there timepoints (preoperative \[PREOP\], postoperative day 1 \[POD1\] , and postoperative day 3\[POD2\]) and postoperative cognitive decline among older adults undergoing orthopedic surgery.
Interventions
None listed
Sponsors
Jia-feng Wang
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
65 Years to 85 Years
Healthy volunteers
Yes
Inclusion criteria
* patients who are more than 65 years old * patients who undergo orthopedic surgery(trauma ,especially fracture of lower limb) * patients with ASA physical status I-III * patients who have a consent
Exclusion criteria
* patients who are more than 85 years old * patients with ASA physical status \>III * patients who have neurological disorders, stroke or other affective central nervous system diseases * patients who have a history of serious psychiatric illness * patients with long-term use of psychoactive substances * patients who undergo multiple trauma and the presence of head injury
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Differences in cytokines levels between the two groups | preoperation | Compare differences in cytokines levels between the two groups |
Countries
China
Contacts
Primary Contactwenbin lu
Outcome results
None listed