Bowel Preparation, Colonoscopy
Conditions
Brief summary
About 30% of patients were reported to suffer inadequate bowel preparation. So, it is desirable to prescribe personalized regimen according to patient's personal characteristics.
Detailed description
Colonoscopy is currently the main approach for detecting mucosal abnormalities in the whole colon. Inadequate bowel preparation is the predominant threaten to the efficacy of colonoscopy.Unfortunately, about 30% of patients were reported to suffer inadequate bowel preparation. In order to improve adequate bowel preparation rate, it is desirable to prescribe personalized regimen according to patient characteristics. We intend to improve adequate bowel preparation rate by deploying tailored bowel preparation strategy. There are many predictive factors of inadequate bowel preparation such as obesity, constipation, abdominal surgery and so on. By recognizing these risk factors of the patients , we can prescribe the patients with higher dose of bowel cleansing regimen to improve bowel preparation quality.
Interventions
DRUG2L Polyethylene Glycol (PEG)
Participants in Group A and Low risk patients in group B are given standard regimen: 2 L Polyethylene Glycol (PEG) regimen
DRUG4L Polyethylene Glycol (PEG)
High risk patients in Group B will receive 4 L Polyethylene Glycol (PEG) regimen
Sponsors
Shandong University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Caregiver, Investigator, Outcomes Assessor)
Intervention model description
Participants are randomly assigned to group A or B. Participants of group A are given normal bowel preparation, while participants of group B are given personalized regimens according to a predictive model we have established.
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* patients aged 18 or older * patients undergoing colonoscopy
Exclusion criteria
* patients with a history of colorectal surgery * patients with severe colonic stricture or obstructing tumor * patients with dysphagia * patients with compromised swallowing reflex or mental status * patients with significant gastroparesis or gastric outlet obstruction * patients with known or suspected bowel obstruction or perforation * patients with severe chronic renal failure (creatinine clearance\<30 ml/min) * patients with severe chronic renal failure (creatinine clearance\<30 ml/min) * patients with uncontrolled hypertension (systolic blood pressure\>170 mm Hg, diastolic blood pressure\>100 mm Hg) * patients with inflammatory bowel disease or megacolon * patients with dehydration * patients with dehydration * patients with pregnancy or lactation * patients hemodynamically unstable * patients unable to give informed consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Adequate bowel preparation rates | 2 months | Adequate bowel preparation rates between 2 groups according to Boston Bowel Preparation Scale (BBPS) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Polyp detection rate | 2 months | Polyp detection rates between 2 groups |
Countries
China
Contacts
Primary ContactLi Yanqing, PhD,MD
Outcome results
None listed