Brugada Syndrome, Early Repolarization Syndrome
Conditions
Brief summary
To determine the values and limitations of ECGI in guiding ablation and risk stratification in patients with BrS and Early Repolarization.
Detailed description
The investigators will study symptomatic BrS and ERs syndrome (N=25) and asymptomatic patients (N=25) age between 16-70 years old to determine values and limitations of non-invasive mapping using electrocardiographic imaging (ECGI) in identifying VF substrates as target sites for catheter ablations in patients with Brugada (BrS) and Early repolarization syndromes (ERS) and also determine the mechanisms of VF in BrS and ERs syndromes.
Interventions
OTHERradiofrequency ablation
Symptomatic patients whose substrates were identified will undergo catheter ablation; asymptomatic patients will be followed without undergoing catheter ablation.
Sponsors
University of Bordeaux
Pacific Rim Electrophysiology Research Institute
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
16 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
Patients presenting with the type1 BrS ECG or ER ECG signature pattern, with/without a sodium channel blocker. Patients with the following one of these symptoms or arrhythmias will be considered as symptomatic patients: 1) aborted cardiac arrest cases, 2) documented VF episodes, 3) agonal respiration during sleep with difficulty to arouse, 4) syncope of unknown origin, or 5) seizure suspected of arrhythmic origin.•
Exclusion criteria
Patients who refuse informed consent and to participate to the best ability in the study. Patients who have structural heart disease or concomitant medical illness.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| VF death | 3 years | ventricular fibrillation |
Countries
Thailand
Outcome results
None listed