Effectiveness of a VAP Prevention Bundle in the PICU

Effectiveness of a Bundle of Ventilator Associated Pneumonia (VAP) Prevention in the Pediatric Intensive Care Unit (PICU): an Observational Study

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03763695

Enrollment

242

Registered

2018-12-04

Start date

2018-01-01

Completion date

2020-06-30

Last updated

2018-12-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ventilator Associated Pneumonia

Keywords

Pediatric intensive care unit, Oral Hygiene Care, Chlorhexidine, Broncho-alveolar lavage, Pharyngeal swab

Brief summary

This observational monocentric prospective study aims to evaluate the efficacy of new measures for ventilator associated pneumonia (VAP) management in the pediatric population in the pediatric intensive care unit (PICU) of Fondazione Policlinico Agostino Gemelli of 8 beds. The investigators will compare the incidence of VAP in the group of patients in which this protocol has been implemented to a retrospective control group of patients before the new protocol implementation. VAP bundle includes oral care hygiene measures (i.e chlorhexidine swab), to keep clean and dry ventilator circuits and head positioning at 45 degrees.

Interventions

OTHERMeasures for the VAP prevention in the PICU

Oral hygiene care (i.e chlorhexidine swab); clean and dry ventilator circuits; head positioning at 45 degrees.

OTHEREvaluation of VAP incidence before the protocol introduction

evaluation of VAP incidence in our pediatric population of intensive care patients before the implementation of the protocol for VAP prevention

Study design

Observational model

CASE_CONTROL

Time perspective

OTHER

Eligibility

Sex/Gender

ALL

Age

No minimum to 18 Years

Healthy volunteers

Inclusion criteria

* age \< 18 years * patients receiving mechanical ventilation for more than 48 hours

Exclusion criteria

* no informed consent * pregnancy * previous endotracheal antibiotic therapy

Design outcomes

Primary

Measure	Time frame	Description
VAP incidence	From 48 hours after intubation to 48 hours after extubation	Incidence of VAP in pediatric patients intubated for more than 48 hours

Secondary

Measure	Time frame	Description
Prevalence of orotracheal bacterial colonization in ventilated patients	From 48 hours after intubation to 48 hours after extubation	Evaluation of orotracheal bacterial colonization in pediatric patients undergoing mechanical ventilation twice a week

Countries

Italy

Contacts

Primary ContactOrazio Genovese, MD

orazio.genovese@policlinicogemelli.it0630153125

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026