Dental Caries Prevention by a Natural Product

Licorice Versus Standard Preventive Measures for the Prevention of Caries Incidence in Young Egyptian Adults: Randomized Controlled Trial

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03763578

Enrollment

Registered

2018-12-04

Start date

2020-09-01

Completion date

2021-12-30

Last updated

2022-02-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dental Caries

Brief summary

The objective is to conduct an RCT to evaluate the effectiveness of Licorice in comparison to standard caries preventive measures for the prevention of new carious lesions in high caries risk patients.

Detailed description

Research hypothesis (Null hypothesis): The present clinical trial will be conducted to reject or accept the null hypothesis that using Licorice extract mouth wash in addition to standard preventive measures will not differ from using standard preventive measures alone in preventing incidence of new carious lesions. PICOTS: P: Population with high caries risk patients I: Use of licorice. I2: Use of chlorhexidine C: Use of standard preventive measures (tooth brushing, tooth paste, interdental cleaning). O.1: Primary outcome is incidence of new carious lesions T: Time for measurement is 12 months S: A Randomized controlled clinical trial (Parallel study)

Interventions

OTHERLicorice

Natural herbal product

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 25 Years

Healthy volunteers

Inclusion criteria

* Patients with high caries risk, * 18-25 years, * Males or females, * Medically free patients, * Patients approving to participate in the study.

Exclusion criteria

* Patients who were on antibiotic therapy or corticosteroid therapy for 30 days before the examination, * Patients had history of professional cleaning in the last 15 days, * Patients with exposed pulp, * Evidence of parafunctional habits, * Patients with developmental dental anomalies, * Patients undergoing or will start orthodontic treatment, * Patients with removable prosthesis, * Periapical Abscess or Fistula.

Design outcomes

Primary

Measure	Time frame	Description
Incidence of new carious lesions	12 months	Appearance of new carious lesions within the study duration

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026