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The Effect of the ALDH2 Gene Polymorphism on the Propofol Potency for Inducing Loss of Consciousness

The Effect of the ALDH2 Gene Polymorphism on the Propofol Potency for Inducing Loss of Consciousness in Cardiac Patients: a Prospective Observational Study

Status
UNKNOWN
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT03762538
Enrollment
100
Registered
2018-12-03
Start date
2019-02-01
Completion date
2019-12-31
Last updated
2018-12-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Propofol

Keywords

propofol, ALDH2, potency

Brief summary

The aim of this study is to determine whether ALDH2 gene polymorphisms (G/G, G/A A/A) have effect on the potency of propofol.

Interventions

DRUGPropofol

Patients will be induced to unconsciousness using propofol intravenously.

Sponsors

Shanghai Zhongshan Hospital
Lead SponsorOTHER

Study design

Observational model
CASE_ONLY
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
MALE
Age
50 Years to 75 Years
Healthy volunteers
No

Inclusion criteria

* ASA II

Exclusion criteria

* ASA III-IV * OSAS * hepatic and renal insufficiency

Design outcomes

Primary

MeasureTime frameDescription
Effect-site concentrationimmediately after patient lose his/her consciousnesspatient's effect-site concentration when he/she loss consciousness

Contacts

Primary ContactKefang Guo, MD
drguokefang@foxmail.com+86-13817706936

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026