Preeclampsia Severe
Conditions
Brief summary
Realization of transcranial doppler and optic nerve sheath in severe preeclamptic patients to evaluate the impact of nicardipine and labetalol on cerebral hemodynamics.
Interventions
DIAGNOSTIC_TESToptic nerve sheath measurement and transcranial doppler
evaluation of cerebral hemodynamics through measurement of systolic and diastolic velocities and PI in middle cerebral artery. Intracranial pressure will be appreciate by optic nerve sheath value
Sponsors
Hopital Antoine Beclere
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Aged up to 18 years * patient with severe preeclampsia defined by Systolic blood pressure ≥ 140 mmHg and/or diastolic blood pressure ≥ 90 mmHg after 20 weeks of amenorrhea, associated with neurologic troubles, eclampsia of epigastric pain. * Decision by clinician to introduce an antihypertensive therapy by oral route : either labetalol or nicardipine
Exclusion criteria
* history of intracranial expansive processus, surgery or vascular disease * infectious state on probe placement * unilateral anophthalmia
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change of values obtained by ultrasonography optic nerve sheath measurement from baseline to 2 hours post starting infusion of nicardipine or labetalol. | just before treatment and 2 hours after | Variation of values will be studied during a 2 hour time period, starting just before administration of either labetalol or nicardipine by i.v. route |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| variation of diastolic and systolic velocities in middle cerebral artery before and after administration of either labetalol or nicardipine by i.v. route | just before treatment and at 30 minutes to 60 minutes, 2 hours to 3 hours and 6 hours to 8 hours | values are obtained by transcranial doppler |
| variation of PI in middle cerebral artery before and after administration of either labetalol or nicardipine by i.v. route | just before treatment and at 30 minutes to 60 minutes, 2 hours to 3 hours and 6 hours to 8 hours | values are obtained by transcranial doppler |
| proportion of pathologic PI in middle cerebral artery in each group | just before treatment and at 30 minutes to 60 minutes, 2 hours to 3 hours and 6 hours to 8 hours | values are obtained by transcranial doppler |
| proportion of optic nerve sheath up to 5.8 mm in each group | just before treatment and at 30 minutes to 60 minutes, 2 hours to 3 hours and 6 hours to 8 hours | values are obtained by ultrasonography |
| values of optic nerve sheath diameter in each group | At 30 minutes to 60 minutes and 6 hours to 8 hours | values are obtained by ultrasonography |
Countries
France
Contacts
Primary ContactMickaël SOUED
Outcome results
None listed