Iodine Deficiency in Pregnancy, Iodine Excess in Pregnancy, Selenium Deficiency in Pregnancy, Selenium Excess in Pregnancy
Conditions
Brief summary
Two hundred and ninety pregnant women with gestational age less than 20 weeks will be recruited in this study. Selenium and iodine conditions, and risk of thyroid disease will be monitored until termination of pregnancy, with pregnancy outcomes recorded.
Detailed description
The study will recruit 290 pregnant women with gestational age less than 20 weeks. Iodine and selenium condition will be evaluated through dietary recall (on base of Chinese food ingredient information) and biochemical examinations (serum iodine concentrations, urinary iodine concentrations, serum selenium concentrations, etc). The nutritional status of iodine and selenium will be monitored and followed up for all the included subjects throughout the pregnancy. The information of thyroid function and level of anti-TPO and anti-TG will be collected. And all the complications (especially thyroid disease) in pregnancy will also be recorded. All pregnant women will be followed up until the termination of pregnancy, with pregnancy outcomes recorded.
Interventions
OTHERNot applicable (for observational studies)
This study is an observational study. No intervention will be administered for research purposes.
Sponsors
Rongrong Li
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Healthy volunteers
Yes
Inclusion criteria
* Clinical confirmation of being pregnant. * Being within less than 20 weeks of gestationa.
Exclusion criteria
* Being pregnant but over 20 weeks of gestationa. * Mentally or psychologically unstable.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| risk of thyroid disease | From date of participant inclusion until the date of termination of pregnancy, assessed up to 8 months | prevalence of thyroid disease (abnormal thyroid function; development of thyroid antibodies) |
| pregnancy outcomes | From date of participant inclusion until the date of termination of pregnancy, assessed up to 8 months | prevalence of premature birth, stillbirth and abortion |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| prevalence of other pregnant complications | From date of participant inclusion until the date of termination of pregnancy, assessed up to 8 months | prevalence of gestational diabetes mellitus, gestational hypertension, dyslipidemia, etc. |
| prevalence of thyroid disease in neonates | From date of birth to 4 weeks after birth | prevalence of thyroid disease (abnormal thyroid function; development of thyroid antibodies，or findings of thyroid nodules) in neonates |
Outcome results
None listed