Comparison of Hyaluronic Acid and Platelet-rich Plasma Injections

Comparison of Hyaluronic Acid and Platelet-rich Plasma Injection on Pain, Physical Function and Femoral Cartilage Thickness in Patients With Osteoarthritis

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03761472

Enrollment

Registered

2018-12-03

Start date

2019-01-01

Completion date

2020-01-13

Last updated

2020-01-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee Osteoarthritis

Keywords

Osteoarthritis, Hyaluronic acid, Platelet-rich plasma, Injection

Brief summary

This study aims to compare the effects of hyaluronic acid injection and platelet rich plasma injection in terms of pain, physical function and femoral cartilage thickness in short term treatment in patients with knee osteoarthritis.

Detailed description

Platelet-rich plasma and hyaluronic acid injections are both popular treatments and commonly used for treatment of knee osteoarthritis. Even though there are many studies investigating the effectiveness of these treatments, the results are mostly qualitative. Also there are a few studies comparing these two treatment modalities. In this study the investigators aim to compare these modalities both for self-reported data (pain, physical function) and objective measurement data (femoral cartilage thickness via ultrasonography). Patients with unilateral osteoarthritis/unilateral complaint will be included in the study. Unaffected side will be controls for each group.

Interventions

BIOLOGICALHyaluronic acid injection

Hyaluronic acid 48 mg 2.0% in 2.4 ml solution

BIOLOGICALPlatelet-rich plasma injection

Platelet-rich plasma injection 5ml

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* Subject is able to consent * Subject meets Osteoarthritis Research Society International (OARSI) criteria for knee osteoarthritis * Subject has radiographic Kellgren-Lawrence grade 2-3 osteoarthritis * Unilateral osteoarthritis/complaint

Exclusion criteria

* Past or actual knee infection * History of surgery, fracture on knee * Collagen tissue disease * Systemic inflammatory disease (rheumatoid arthritis, spondyloarthritis etc.) * Systemic diseases (diabetes, hematologic diseases, endocrinopathies, renal failure, liver failure) * Knee injection in past 6 months * Immunodeficiency * Pregnant/breastfeeding * Malignancy

Design outcomes

Primary

Measure	Time frame	Description
Change of numeric rating scale (rest, movement)	0, 1st, 6th, months	Self reported pain scored between 0 (minimum)-10 (maximum). Higher scores represent a worse outcome.
Change of Western Ontario and McMaster Universities Osteoarthritis Index score(WOMAC)	0, 1st, 6th months	Self reported questionnaire investigating 24 daily living activities. Each item is scored 0-5 (0:none 5:worst). Yielding a total between 0-100. Higher scores represent a worse outcome.
Change of femoral cartilage thickness via ultrasonography.	0, 1st, 6th months	Transverse plane femoral cartilage thickness from three landmarks (from articular cartilage pothole,from midpoint of medial border and pothole of cartilage, from midpoint of lateral border and pothole of cartilage). Measured in millimeters. The sum of three points indicate a total thickness. A higher measurement indicates a thicker cartilage representing a better outcome.

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026