Pediatric Low-grade Gliomas
Conditions
Keywords
Neuro Oncology
Brief summary
This research study is evaluating the investigational software for magnetic resonance imaging (MRI) systems and techniques to process magnetic resonance (MR) images
Detailed description
The purpose of the study is to develop new technologies for MRI systems. The new technologies should improve MRI capabilities in terms of how sensitive, specific, and efficient they are. The overall goal is to get better measurements of the brain tumor tissue(s). In this research study, the investigators want to learn more about investigational software and about techniques to process MR images. The testing of investigational software will allow the investigators to improve the image quality. As part of the testing process, the investigators will collect more MR images of the brain, and improve current image reconstruction methods. This will allow a more precise analysis of MR images and potentially better assessment of the brain tumor tissue volume.
Interventions
OTHERWave-CAIPI
wave-CAIPI technology, a data acquisition / reconstruction scheme designed to optimally exploit available information in modern multi-channel receivers and in multi-contrast/time-series data for improved image encoding
Sponsors
National Institute for Biomedical Imaging and Bioengineering (NIBIB)
Dana-Farber Cancer Institute
Boston Children's Hospital
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
ALL
Age
0 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Infants, children and adults who have been diagnosed with Low Grade Glioma * Healthy volunteers - Children from age 0 to adults with no upper age limit or; * Diagnosed with LGG and being treated at DFCI;
Exclusion criteria
* Electrical implants such as cardiac pacemakers or perfusion pumps; * Ferromagnetic implants such as aneurysm clips, surgical clips, prosthesis, artificial hearts, valves with steel parts, metal fragments, shrapnel, tattoos near the eye, or steel implants; * Ferromagnetic objects such as jewelry or metal clips; * Women of childbearing age who are seeking to become pregnant, who are breastfeeding, or who suspect they may be pregnant; * Pre-existing medical conditions including a likelihood of developing seizures or claustrophobic reactions; * Any greater than normal potential for cardiac arrest
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Wave-CAIPI validation | 2 years | The outcome measure for this project will be that the rapid scan from Wave-CAIPI can provide equivalent diagnostic quality to that of standard clinical acquisitions which is performed at much slower speed. This will be assess using visual qualitative assessment by experienced radiologists on the project. |
Countries
United States
Contacts
Primary ContactKawin Setsompop, PhD
Outcome results
None listed