The Change of Gut Microbiota After Bowel Preparation and the Effect of Probiotics

The Change of Gut Microbiota After Bowel Preparation and the Effect of Probiotics: Randomized Controlled, Open-label Trial

Status

Completed

Phases

Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03760133

Enrollment

100

Registered

2018-11-30

Start date

2018-12-01

Completion date

2019-12-31

Last updated

2020-02-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bowel Preparation, Colonoscopy, Gut Microbiota

Keywords

Gut microbiota, Colonoscopy, Bowel preparation, Probiotics

Brief summary

The purpose of this study is to investigate the relationship between the change of intestinal bacterial flora and the recovery, and the incidence of symptoms such as abdominal discomfort after colonoscopy. And the investigators will also analyze the effects of probiotics on the degree of change, recovery, and symptom development in intestinal flora.

Detailed description

The investigators divided two groups. (total number = 100 subjects) 1. with probiotics group - 50 subjects * Participants included in this group will be taken probiotics for 1 month after bowel preparation for colonoscopy. 2. without probiotics group - 50 subjects * Participants included in this group will not be taken probiotics for 1 month after bowel preparation for colonoscopy.

Interventions

DRUGDuolac

Participants included in this group will be taken probiotics for 1 month after bowel preparation for colonoscopy.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

OTHER

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

30 Years to 70 Years

Healthy volunteers

Yes

Inclusion criteria

* adults between the age of 30 and 70

Exclusion criteria

* subjects with cancer or IBD (inflammatory bowel disease) * subjects with history of abdominal surgery * subjects who take medication related to gastrointestinal motility within 3 months * subjects who take antibiotics within 3 months

Design outcomes

Primary

Measure	Time frame	Description
The effect of probiotics on the change of gut microbiota after bowel preparation.	eight months	Analysis the change of gut microbiota before and after bowel preparation for colonoscopy, and the effect of probiotics.

Secondary

Measure	Time frame	Description
The occurrence of symptoms	eight months	Analysis the occurrence of symptoms including abdominal discomfort, diarrhea, constipation or abdominal blotting after bowel preparation for colonoscopy.
The correlation between symptoms and gut microbiota..	eight months	Analysis the the correlation between the symptoms after bowel preparation for colonoscopy and the changes of gut microbiota.

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026