Angiomatoid Fibrous Histiocytoma: a Single Institution Case-series

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03759327

Enrollment

Registered

2018-11-30

Start date

2018-11-30

Completion date

2019-05-25

Last updated

2020-02-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Angiomatoid Fibrous Histiocytoma

Brief summary

single institution cases series review of histological and clinical data

Detailed description

single institution cases series review of histological and clinical data Investigators will retrieve from the archives of the Rizzoli Institute all the cases with a histological diagnosis of Angiomatoid Fibrous Histiocytoma. In all cases with enough available material, immunohistochemistry will be performed on slides/formalin-fixed paraffin-embedded tissue tumor material.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

OTHER

Eligibility

Sex/Gender

ALL

Inclusion criteria

* Male and female patients treated at Rizzoli Institute from 01 January 2006 to 31 December 2017 * Diagnosis of Angiomatoid Fibrous Histiocytoma * Histological slides/formalin-fixed paraffin-embedded tissue tumor (FFPE) blocks from archive available to perform the histology analysis * Written informed consent prior to any study-specific analysis and/or data collection

Exclusion criteria

• Patients with histological diagnosis different from Angiomatoid Fibrous Histiocytoma

Design outcomes

Primary

Measure	Time frame	Description
selection and review of 9 cases of Angiomatoid Fibrous Histiocytoma	at baseline (Day0)	investigators will review all the medical records, radiological imaging, and histological slides of all cases to identify the best therapeutic approach.
analysis of EWS-CREB1 and EWS-ATF1 mutation and ALK expression on tissue tumor material	at baseline (Day0)	In all cases immunohistochemistry will be performed on slides/formalin-fixed paraffin-embedded tissue tumor material. EWS-CREB1 and EWS-ATF1 mutation and ALK expression will be analyzed with RT-PCR and/or FISH analysis.

Countries

Italy

Outcome results