Cardiovascular Diseases, Carotid Intimal Media Thickness, Children, End Stage Renal Disease, Hemodialysis Complication, Left Ventricular Hypertrophy, Mean Platelet Volume, Peritoneal Dialysis Complication
Conditions
Brief summary
Cardiovascular disease (CVD) is the major risk factor for death in end stage renal diseases (ESRD). Approximately 80% of ESRD patients have some degrees of left ventricular abnormalities at initiation of dialysis. Carotid intima media thickness (CIMT) has been widely accepted as an useful marker to assess CVD in ESRD children. In addition, cardiac mechanics parameters are used to evaluate cardiac function more precisely. However, measuring CIMT and cardiac mechanics parameters are expensive and difficult to perform as a routine method. Mean platelet volume (MPV) is a hematological index which shows the size of platelets. Uremic state causes inflammatory condition that affects MPV. Previous studies on people with normal renal function have shown that this parameter can also have association with CVD. However the data in children with ESRD is scarce. The aim of this study is to find a simple hematologic marker to use regularly in ESRD children finding patients at risk of CVD. Therefore, we will investigate the relationship between mean platelet volume and CIMT and cardiac mechanic parameters in children with ESRD.
Interventions
DIAGNOSTIC_TESTImaging
Imaging including Echocardiography for determining cardiac indices (ejection fraction, left ventricular mass index, strain rate, global longitudinal strain) and Doppler ultrasound for measuring carotid intima media thickness
OTHERBlood sampling
Blood sampling will performed on all participants for measuring hematological parameters including MPV.
Sponsors
Isfahan University of Medical Sciences
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
No minimum to 18 Years
Healthy volunteers
Yes
Inclusion criteria
* Children under 18 years who have being dialyzed (hemodialysis or peritoneal dialysis) regularly more than 6 months, as case group. * Age and gender matched healthy children who have been referred for routine medical examination.
Exclusion criteria
* Patients with uncontrolled hypertension (until being stabled) * Patients on any kind of antithrombotic agents or NSAIDs * Severe obesity * Diabetes patients * Patients with a past history of CVD or stroke in the last 6 months * Passive smokers who contacted daily with high smokers in their houses * Patients with known hematologic diseases or malignancies (such as Fanconi Anemia) * Uncontrolled hypothyroid or hyperthyroid patients * Patients with recent (in the last 4 weeks) catheter or exit -site infection.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Correlation between MPV and carotid intima media thickness | 2 years after study beginning | Determining correlation between the value of MPV with carotid intima media thickness in patients |
| MPV in patients and controls | 1 year after study beginning | Comparing the mean of MPV in patients and controls. |
| Echocardiographic indices in patients and controls | 1.5 years after study beginning | Comparing the means of echocardiographic indices in patients and controls |
| Carotid intima media thickness in patients and controls | 2 years after study beginning | Comparing the mean of carotid intima media thickness in patients and controls |
| Correlation between MPV and ejection fraction | 1.5 years after study beginning | Determining correlation between the value of MPV with ejection fraction in patients |
| Correlation between MPV and left ventricular mass index | 1.5 years after study beginning | Determining correlation between the value of MPV with left ventricular mass index in patients |
| Correlation between MPV and strain rate | 1.5 years after study beginning | Determining correlation between the value of MPV with strain rate in patients |
| Correlation between MPV and global longitudinal strain | 1.5 years after study beginning | Determining correlation between the value of MPV with global longitudinal strain in patients |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| MPV and thrombotic events | 2 years after study beginning | Comparing the values of MPV in patients with and without previous histories of thrombotic events including arteriovenous fistula thrombosis, cerebrovascular accident, deep venous thrombosis, and cerebrovascular accident |
Outcome results
None listed