Respiratory Insufficiency
Conditions
Keywords
Breathing Exercises, Respiratory Muscles, Respiration Artificial, Weaning
Brief summary
The long stay in mechanical ventilation can induce several complications, among them respiratory muscle weakness, this has been related to the duration of mechanical ventilation, delay and failure to wean, resulting in longer hospitalization, which reflects in greater care increase in hospital costs. Therefore, of this research will be to compare the effectiveness of early inspiratory muscle training (IMT) versus non-IMT in patients undergoing mechanical ventilation to improve the outcome of mechanical ventilation weaning time.
Detailed description
The study will consist of a randomized controlled clinical trial conducted at the Intensive Care Unit of the University Hospital of UNIVASF. Will be included individuals of both sexes, aged 18 years or older, who are on invasive mechanical ventilation and who obtain the Free and Informed Consent Form, signed by the responsible family member. Subjects will be randomized into two groups (training and control). The inspiratory (MIP), expiratory (MEP) and peak expiratory flow pressures will be evaluated. The training group will perform respiratory muscle training, using the Powerbreath equipment, with initial loading of 40% of MIP, 7 days a week, 2 times a day. Morbidities that have repercussions on diaphragmatic contraction and end-stage disease will be used as exclusion criteria. The sample data will be analyzed through the SPSS 22.0 program. The significance level of the study will be set at 5% (p \<0.05).
Interventions
OTHERInspiratory Muscle Training (IMT)
Inspiratory Muscle Training (IMT)
OTHERIntensive Physiotherapy (IPT)
Intensive Physiotherapy (IPT)
Sponsors
Universidade Federal do vale do São Francisco
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Investigator, Outcomes Assessor)
Intervention model description
Compare the effectiveness of early inspiratory muscle training (IMT) versus non-IMT in patients undergoing mechanical ventilation to improve the outcome of mechanical ventilation weaning time.
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* invasive mechanical ventilation * patients hemodynamically stable * without use of vasoactive drugs
Exclusion criteria
* spindle trauma * neuromuscular diseases * end-stage disease * pneumothorax * rib fracture * diaphragmatic injury * postoperative pulmonary surgeries * abdominal disease * morbidities that have repercussions on diaphragmatic contraction * mechanical ventilation with FiO2 \> 60% and PEEP \> 10 cm H2O
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Weaning mechanical ventilation | through study completion, an average of 15 days | time of mechanical ventilation |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| length of stay in the ICU | through study completion, an average of 15 days | reduction length of stay in the ICU |
| extubation success | through study completion, an average of 2 days | extubation success after 48 hours |
| death | yes or not death, through study completion, an average of 15 days | reduction in mortality (death) |
Countries
Brazil
Contacts
Primary ContactRodrigo GS Carvalho, PhD
Backup ContactRodrigo GS Carvalho, PhD
Outcome results
None listed