PTSD, Trauma
Conditions
Brief summary
The research goal is to uncover the neurocognitive moderators of PTSD trajectories, by documenting clinical symptoms, cognitive functioning, and brain structure and function, one-, six- and fourteen months following a traumatic event, in a large population of survivors at initial high risk for PTSD.
Interventions
None listed
Sponsors
Tel-Aviv Sourasky Medical Center
New York University
Texas A&M University
National Institute of Mental Health (NIMH)
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Age 18 - 65 years * Able to read and comprehend Hebrew * Arrived in the ER because of one of the following: car accidents, terrorist attacks, work accidents, home accidents, burns, physical assault, large-scale disaster.
Exclusion criteria
* Individuals with known claustrophobia * Individuals with history of substance abuse * Individuals with current or past psychotic or bipolar I disorder * Individuals with chronic PTSD at the time of the current trauma * Individuals on psychotropic medication or recreational drugs in the week that precedes the MRI * Individuals with hearing problems * Individuals with head trauma with coma exceeding 30 minutes * Individuals which can't perform MRI due to safety reasons (e.g. irremovable metals in their body)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in CAPS Total Scores | one-, six- and fourteen months following a traumatic event | The Clinician-Administered PTSD Scale, used to assess PTSD diagnostic status and symptom severity. CAPS total symptom severity score is calculated by summing severity scores for all PTSD symptoms. We use both CAPS-V (according to DSM-4) and CAPS-5 (according to DSM-5). |
Countries
Israel
Outcome results
None listed