Obesity
Conditions
Keywords
Obesity, Appetite regulation, Chronotype, Diet
Brief summary
BACKGROUND: Several reports have observed that the alteration of normal biological rhythms is associated with obesity development. In this regard, those subject with the preference for evening seems to be prone to develop obesity. However, the current treatment of obesity does not take into account these aspects OBJECTIVE: To evaluate whether a diet adjusted to patient's chronotype is more effective than the current dietary recommendations. SUBJECTS/METHODS: 209 subjects take part in a randomized, double-blind clinical trial. 104 subjects followed a typical hypocaloric dietary treatment (CONTROL) and the other 105 subjects undergone a diet with a daily caloric distribution adjusted to their chronotype (CHRONO). CONCLUSIONS: A chronotype-adjusted diet may be a promising alternative to the classical hypocaloric dietary treatment since the investigator's data indicate a higher effectiveness regarding weight loss when the diet was adjusted to the patient's chronotype.
Interventions
PROCEDURECHRONOTYPE-ADJUSTED DIET
Those patients followed a daily caloric distribution attending to their chronotype. In this regards, 'morning' subjects ate a higher quantity of calories at the first part of the day, while 'evening' subjects ate a higher amount of calories at the second half of the day.
Sponsors
Hospital Universitario Virgen de la Arrixaca
Universidad Católica San Antonio de Murcia
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* students or staff of the Catholic University of Murcia (UCAM), with an age ranged between 18 and 65 years old
Exclusion criteria
* clinically significant illnesses (including type 2 diabetes, chronic heart failure, hepatitis and cancer) * those taking any medications known to affect body weight (thyroid hormones, corticosteroids, etc.) * women in special physiological situations (pregnant, lactating).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Total weight loss, in percentage, from baseline to end-of-treatment | 12 weeks | Percentage of weight loss, measured with a scale, from baseline weight (100% body weight) since body weight after 12 weeks of treatment (final body weight). Percentage of body weight was then measured as Total Weight Loss (%) = (Final body weight - Baseline body weight) / baseline body weight x 100. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Anthropometrical and other clinical parameters | 12 weeks | Improvement of anthropometrical and other clinical parameters during the treatment |
| BMI loss | 12 weeks | BMI decrease from baseline |
Outcome results
None listed