Hypothyroidism, Pregnancy Early, Thyroid, Thyroid Dysfunction
Conditions
Keywords
TSH
Brief summary
Physiological changes necessitate the use of pregnancy-specific reference ranges for TSH and FT4 to diagnose thyroid dysfunction during pregnancy. Although many centers use fixed upper limits for TSH of 2.5 or 3.0 mU/L, this may lead to overdiagnosis or even overtreatment. The new guidelines of the American Thyroid Association have considerably changed recommendations regarding thyroid function reference ranges in pregnancy accordingly. Any hospital or physician that is still using the 2.5 or 3.0 mU/l cut-off for TSH during pregnancy should evaluate their own lab-specific cut-offs. The investigator's objective is to establish a rational reference range of serum TSH for diagnosis of subclinical hypothyroidism in the first and second trimester of pregnant women in west Black Sea region in Turkey.
Detailed description
Serum thyroid function tests (including T3, T4, TSH, Anti-TPO) will be obtained from the singleton pregnancies in first and second trimester to determine the local specific normal ranges.
Interventions
DIAGNOSTIC_TESTSerum thyroid functions tests
Serum TSH, fT3, fT4 and anti-TPO
Sponsors
Bartin State Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Singleton pregnancy * Free of pre-existing thyroid disease * That do not use thyroid interfering medication * That did not undergo IVF treatment * TPOAb negative
Exclusion criteria
* Adolescent pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| TSH | Day 1 | Serum TSH (mU/I) |
Countries
Turkey (Türkiye)
Contacts
Primary ContactMurat Yassa, MD
Outcome results
None listed