Syphilis
Conditions
Keywords
syphilis, serofast
Brief summary
Some syphilitic patients remain in a serologically positive state after the recommended therapy. Whether a serofast state could represent a persistent low-level infection by Treponema pallidum is still unknown. The possibility that persistent nontreponemal antibodies after treatment represent persistence of Treponema pallidum was raised by some investigators. The investigators use the Next-Generation Sequencing to test blood plasma, srum, cerebrospinal fluid, aqueous humor, lymph nodes, skin lesion, saliva, semen,milk of serofast patient and other positive and negative controls.
Detailed description
Some syphilitic patients remain in a serologically positive state after the recommended therapy. Whether a serofast state could represent a persistent low-level infection by Treponema pallidum is still unknown. The possibility that persistent nontreponemal antibodies after treatment represent persistence of Treponema pallidum was raised by some investigators. The investigators use the Next-Generation Sequencing to test blood plasma, serum, cerebrospinal fluid, aqueous humor, lymph nodes, skin lesion, saliva, semen,milk of serofast patient and other positive and negative controls.
Interventions
DIAGNOSTIC_TESTRPR Titer
RPR titer; TPPA/FTA-ABS; Next-Generation Sequencing
Sponsors
Peking Union Medical College Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
* All clinical diagnosis of syphilis cases
Exclusion criteria
* Auto-immune disease (such as SLE) * Lyme disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| the reads of treponema pallidum | 30 days | Using the Next-Generation Sequencing to test specific genome of treponema pallidum for syphilis |
Countries
China
Contacts
Primary ContactJun Li
Outcome results
None listed