Perfusion and Dual Energy Computer Tomography in Hepatocellular Carcinoma

Prediction Value of Perfusion and Dual Energy Computer Tomography for Microvascular Invasion in Hepatocellular Carcinoma

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03754192

Acronym

PERCAHEC

Enrollment

Registered

2018-11-27

Start date

2019-01-30

Completion date

2020-12-30

Last updated

2020-09-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hepatocellular Carcinoma

Keywords

Perfusion computer tomography, dual-energy computer tomography

Brief summary

The aim of this study is to evaluate the hepatic perfusion computer tomography and dual energy computer tomography in the assessment of tumor characterization of Hepatocellular carcinoma in patients with resectable Hepatocellular carcinoma by comparing the quantitative parameters computer tomography obtained with the pathological data of the surgical specimens.

Detailed description

Dual-energy computer tomography and perfusion computer tomography (General Electric revolution Hight definition Gemstone™ Spectral Imaging) will be performed in all patients. Iodine concentration and quantitative perfusion parameters of the Hepatocellular carcinoma and surrounding liver parenchyma data will be compared with the pathological results.

Interventions

RADIATIONperfusion Computed Tomography

Will be carried before liver surgery

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

NONE

Intervention model description

Dual-energy computed tomography and perfusion computed tomography

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* A diagnosis of Hepatocellular carcinoma made according to the guidelines of the American Association for the study of the Liver * Affiliation to a national health insurance * An indication for hepatic resection during the decision-making stage * A request for a pre-operative Computer Tomography in our radiology unit * An affiliation to a social security * Informed consent given by the patient

Exclusion criteria

* Previous treatments of Hepatocellular carcinoma (medicated or surgical) * Patient under tutorship or curatorship * Pregnant or lactating woman

Design outcomes

Primary

Measure	Time frame	Description
Pefusion parameters	5 minutes	correlation between pre-operative imaging data and histological data of Hepatocellular carcinoma

Secondary

Measure	Time frame	Description
Pathological examination	1 month	Compare data obtained in perfusion computer tomography to the imaging data and to the Histological differentiation grades

Countries

France

Contacts

Primary ContactLEWIN MAITE, MD, Phd

maite.lewin@aphp.fr00 (33) 6 11 15 06 17

Backup ContactDA-MOTA-FERREIRA Jean-Manuel, Radiologic

jean-manuel.da-mota-ferreira@aphp.fr00 (33) 145592474

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 18, 2026