Exome Sequencing Study in Cardiomyopathy to Identify New Risk Variants

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03754101

Enrollment

4000

Registered

2018-11-27

Start date

2003-03-03

Completion date

2025-10-31

Last updated

2023-02-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiomyopathy

Brief summary

Genetic mutations has been proved to be associated wth the onset of cardiomyopathy. In the present study, we intend to identify new related variants or genes. From March, 2003 to November, 2017, patients diagnosed as cardiomyopathy were consecutively recruited, and their sampled were drawn from peripheral blood. Paired control group were also enrolled. The whole exome sequencing was used to find out the variants associated with the onset of cardiomyopathy and its prognosis.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Yes

Inclusion criteria

· Patients diagnosed as cardiomyopathy according to the definition of American Heart Association

Exclusion criteria

* Uncontrolled hypertension significant valvular disease * Mild ischemic heart disease * Significant systemic infection * Thyroid-induced cardiomyopathy * Excessive alcohol consumption * Precious cancer treatment including irradiation * Refusal to participate in the study

Design outcomes

Primary

Measure	Time frame	Description
Cardiovascular death confirmed by death comfirmation or interview with the relatives	up to 24 months	Death from cardiovascular causes and any unknown death unless there was another certain cause
Heart transplantation confirmed by medical record	up to 24 months	Heart transplantation within 24 months

Secondary

Measure	Time frame	Description
All cause death confirmed by death comfirmation or interview with the relatives	up to 24 months	Any death at hospital or after discharge
Heart failure recurring confirmed by medical record	up to 24 months	Recurrence of heart failure at hospital or after discharge

Other

Measure	Time frame	Description
Readmission because of cardiovascular diseases confirmed by medical record	up to 24 months	Readmission because of cardiovascular diseases within 24 months

Countries

China

Contacts

Primary ContactChenze Li, MD candidate

lichenze@126.com86-27-83663280

Outcome results