Central Venous Pressure (CVP) Changes do Not Predict Preload Unresponsiveness

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03753672

Enrollment

Registered

2018-11-27

Start date

2017-12-10

Completion date

2019-06-30

Last updated

2019-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiovascular Shock

Brief summary

Passive leg raising (PLR) is routinely used to predict preload responsiveness in critically ill patients. However, real-time measurements of cardiac output are required to assess its effects. Some authors have suggested that in fluid non-responders, central venous pressure (CVP) increased markedly. By analogy with the CVP rules proposed by Weill et al to assess a fluid challenge, it has been hypothesized that an increase in CVP ≥ 5 mmHg during PLR can predict preload unresponsiveness. Objective Investigation of whether an increase in CVP ≥ 5 mmHg during PLR predict preload unresponsiveness diagnosed by the absence of increase in velocity-time integral (VTI) of the flow in the left ventricular outflow tract by more than 10% (4). Methods Critically ill patients with a central venous catheter in place and for whom the physician decided to test preload responsiveness by PLR were prospectively included. Transthoracic echocardiography was performed to obtain VTI. The CVP and VTI were measured before and during PLR.

Interventions

DIAGNOSTIC_TESTpreload responsiveness

We investigated whether an increase in CVP ≥ 5 mmHg during PLR predict preload unresponsiveness diagnosed by the absence of increase in velocity-time integral (VTI) of the flow in the left ventricular outflow tract by more than 10%

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* ADULTS * Patients presenting with shock or other signs of circulatory failure (tachycardia, oliguria) * Need for the physician to test preload responsiveness * Patients already equipped by a central venous catheter for the measurement of CVP

Exclusion criteria

* patients\<18 years old * pregnancy * instaility justifying rapid increase in cathecolamines

Design outcomes

Primary

Measure	Time frame	Description
the predictive value of changes in CVP to determine preload responsiveness	ONE MINUTE TEST	Systolic, diastolic and mean arterial pressure will be assessed before and after the PLR test

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026