Acute Kidney Injury, Cardiorenal Syndrome
Conditions
Brief summary
The prospective single-center study investigates the association between changes in Doppler-derived renal venous flow and cardiac surgery-associated acute kidney injury (CSA-AKI).
Detailed description
CSA-AKI is a common postoperative complication in patients undergoing open heart surgery, and is associated with increased mortality and morbidity. Venous congestion has been identified as the principal cause of cardiorenal decompensation in patients with heart failure but the relative contribution of congestion-driven renal function decline in CSA-AKI is not well studied. The prospective single-center study investigates whether serial Doppler-derived renal venous flow assessments could help identify subset of patients with cardiorenal syndrome and subclinical renal congestion at high risk of CSA-AKI.
Interventions
OTHERNo intervention
No intervention
Sponsors
University of Giessen
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Inclusion criteria: 1. Subjects older than 18 years 2. Subjects undergoing elective cardiac surgery (with or without cardiopulmonary bypass) 3. Subjects who signed informed consent forms
Exclusion criteria
1. Patients requiring mechanical ventilation 2. Patients with mechanical circulatory assist devices or extracorporeal membrane oxygenation 3. Patients with stage 3 AKI with renal replacement therapy (RRT) or life- threatening volume overload treated with RRT 4. Stage ≥4 chronic kidney disease (CKD) stage 5. CKD requiring extracorporeal or peritoneal ultrafiltration for diuretic-resistant volume overload, 6) 6) Prediagnosed glomerulonephritis 6. Autosomal dominant polycystic kidney disease, postrenal obstruction, or solid organ transplantation 7. Anticipated life expectancy of \<12 months 8. Likelihood of receiving advanced therapy (mechanical circulatory assist device/cardiac transplant) 9. Pregnancy or possibility of pregnancy in the next 3 months 10. Rhabdomyolysis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Association between perioperative changes in Doppler-derived renal venous venous flow and CSA-AKI | preoperative, 24 hours postoperative, hospital discharge | Doppler-derived renal venous flow |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Association of changes in postoperative renal venous flow profiles with renal recovery at hospital discharge | Measured at Day 1 and Day 7 postoperative | Doppler-derived renal venous flow |
| Estimated GFR trajectory up to 3 months post-cardiac surgery relative to kidney | Measured at 3 months post-surgery | Estimated GFR |
Countries
Germany
Outcome results
None listed