Avascular Necrosis of the Femoral Head
Conditions
Keywords
Total hip arthroplasty, Total hip replacement
Brief summary
1. The course of AVN between Initial diagnosis and total hip replacement (THA) is analysed. The impact of early interventions versus conservative therapy in AVN before THA will be evaluated. 2. The short and long term outcomes of AVN patients undergoing THA with respect to complications, reoperations and quality of life are investigated. Potential risk factors for adverse outcomes will be investigated.
Detailed description
The study is to describe the course of avascular necrosis (AVN) of the femoral head from initial diagnosis and to collect data on treatment options and the further course in these cases. The duration from initial diagnosis of AVN to joint replacement as total hip arthroplasty (THA) will be analysed and the course after joint replacement with potential short- and long-term complications will be evaluated. The impact of THA after AVN on activities of daily living will be assessed by Euroquol 5 Dimensions (EQ-5D-5L) and Hip disability and Osteoarthritis Outcome Score (HOOS) questionnaires.
Interventions
OTHERquestionnaires for patient reported outcome
questionnaires with respect to outcomes: * Reoperations * Short term complications * Long term complications * EQ-5D (current) * HOOS (current) * disease related change of occupation * use of walking aids * comorbidities * medication
OTHERquestionnaire for course of the disease
questionnaires to assess course of the disease: * from initial diagnosis of AVN to joint replacement as total hip arthroplasty (THA) * therapeutic interventions
Sponsors
University Hospital, Basel, Switzerland
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* MRI of the hip available from diagnosis at the USB or KSBL Liestal * Informed Consent
Exclusion criteria
* Insufficient knowledge of project languages (English, German, French)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| arthroplasty-free interval (time until THA) | single time point assessment at baseline | time from first diagnosis of AVN to joint replacement = time to event data (in the years between 1999-2006) |
| rate of reoperations after THA | single time point assessment at baseline | reoperation after THA = time to event data (in the years between 2000-2007) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Hip disability and Osteoarthritis Outcome Score (HOOS) | single time point assessment at baseline | 40 item questionnaire to assess patient-relevant outcomes in five separate subscales (pain, symptoms, activity of daily living, sport and recreation function and hip related quality of life). Scores are: None, Mild, Moderate, Severe, Extreme |
| Euroquol 5 Dimensions (EQ-5D-5L) | single time point assessment at baseline | Five dimensions: mobility, self-care, usual activities, pain/discomfort and anxiety/depression. Each dimension has 5 levels: no problems, slight problems, moderate problems, severe problems and extreme problems. |
Outcome results
None listed